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Overview

Uniprot IDI3LI05
Protein NameSerrate RNA effector molecule homolog
Gene NameSRRT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
441 AEIISLCKRYPGFMR
709 SNTQELGKDKWLCPL
711 TQELGKDKWLCPLSG
722 PLSGKKFKGPEFVRK

Function

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription

Protein Sequence

10 MGDSDDEYDR 20 RRRDKFRRER 30 SDYDRSRERD 40 ERRRGDDWND 50 REWDRGRERR 60 SRGEYRDYDR 70 NRRERFSPPR 80 HELSPPQKRM 90 RRDWDEHSSD 100 PYHSGYEMPY 110 AGGGGGPTYG 120 PPQPWGHPDV 130 HIMQHHVLPI 140 QARLGSIAEI 150 DLGVPPPVMK 160 TFKEFLLSLD 170 DSVDETEAVK 180 RYNDYKLDFR 190 RQQMQDFFLA 200 HKDEEWFRSK 210 YHPDEVGKRR 220 QEARGALQNR 230 LRVFLSLMES 240 GWFDNLLLDI 250 DKADAIVKML 260 DAAVIKMEGG 270 TENDLRILEQ 280 EEEEEQAGKP 290 GEPSKKEEGR 300 AGQGLGDGER 310 KANDKDDKKE 320 DGKQAENDSS 330 SDDKTKKSEG 340 DGDKEEKKED 350 AEKETKKSSK 360 KRNRKHSGDD 370 SFDEGSVSES 380 ESESESGQAE 390 EEKEEAEDAV 400 KEKEKPKEEE 410 REKPKDAPGL 420 ECKPRPHKTC 430 SLFMRNIAPN 440 ISRAEIISLC 450 KRYPGFMRVA 460 LSEPQPERRF 470 FRRGWVTFDR 480 SVNIKEICWN 490 LQNIRLRECE 500 LSPGVNRDLT 510 RRVRNINGIT 520 QHKQIVRNDI 530 KLAAKLIHTL 540 DDRTQLWASE 550 PGTPPLPTSL 560 PSQNPILKNI 570 TDYLIEEVSA 580 EEEELLGSSG 590 GAPPEEPPKE 600 GNPAEINVER 610 DEKLIKVLDK 620 LLLYLRIVHS 630 LDYYNTCEYP 640 NEDEMPNRCG 650 IIHVRGPMPP 660 NRISHGEVLE 670 WQKTFEEKLT 680 PLLSVRESLS 690 EEEAQKMGRK 700 DPEQEVEKFV 710 TSNTQELGKD 720 KWLCPLSGKK 730 FKGPEFVRKH 740 IFNKHAEKIE 750 EVKKEVAFFN 760 NFLTDAKRPA 770 LPEIKPAQPP 780 GPAQILPPGL 790 TPGLPYPHQT 800 PQGLMPYGQP 810 RPPILGYGAG 820 AVRPAVPTGG 830 PPYPHAPYGA 840 GRGNYDAFRG 850 QGGYPGKPRN 860 RMVRGDPRAI 870 VEYRDLDAPD DVDFF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016604 nuclear body
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0140262 mRNA cap binding complex binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0097150 neuronal stem cell population maintenance
Biological Process GO:0050769 positive regulation of neurogenesis
Biological Process GO:0031053 primary miRNA processing
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.