Overview
| Uniprot ID | I3LJY8 |
|---|
| Protein Name | Very-long-chain 3-oxoacyl-CoA reductase |
|---|
| Gene Name | HSD17B12 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 72 |
SYAEELAKRGMKIVL |
Function
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation
Protein Sequence
10
METALPAAGF
20
LYWVGASTVA
30
YLALRISCWF
40
FTALRVWGLG
50
HEAGVGPWLG
60
EWAVVTGGTD
70
GIGKSYAEEL
80
AKRGMKIVLI
90
SRSQDKLDQV
100
SSEISEKFKV
110
ETKTIAVDFT
120
SEDIYDKIKA
130
SLAGLNIGVL
140
VNNVGMSYEY
150
PEYFLDVPDL
160
DNTIKKLITV
170
NALSVCKMTR
180
LVLPGMVERS
190
KGAILNISSA
200
SGMYPVPLLT
210
IYSATKAFVD
220
FFSQCLHEEY
230
KSKGVIVQSV
240
LPYYVATKLA
250
KIKRPTWDKP
260
SPETFVKSAM
270
KTIGVQSRTN
280
GYPIHSLVAS
290
VSASLPSWLY
300
FKIAMYSGNS
310
IRVRYLKKMK
MN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0009923 |
fatty acid elongase complex |
| Molecular Function |
GO:0005518 |
collagen binding |
| Molecular Function |
GO:0004303 |
estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| Molecular Function |
GO:0001968 |
fibronectin binding |
| Molecular Function |
GO:0008201 |
heparin binding |
| Molecular Function |
GO:0016491 |
oxidoreductase activity |
| Molecular Function |
GO:0047045 |
testosterone dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0141040 |
very-long-chain 3-oxoacyl-CoA reductase activity |
| Biological Process |
GO:0006702 |
androgen biosynthetic process |
| Biological Process |
GO:0006703 |
estrogen biosynthetic process |
| Biological Process |
GO:0019367 |
fatty acid elongation, saturated fatty acid |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.