Search Results
Overview
| Uniprot ID | I3LK13 |
|---|---|
| Protein Name | Ras-related GTP-binding protein |
| Gene Name | RRAGB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 203 | DQRDLIFKEREEDLR |
| 291 | RDAHRFEKISNIIKQ |
| 297 | EKISNIIKQFKLSCS |
Function
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade
Protein Sequence
10
MEESDSEKKM
20
EKENVGSRMD
30
PPIGEPEGSL
40
GWVLPNTAMK
50
KKVLLMGKSG
60
SGKTSMRSII
70
FANYIARDTR
80
RLGATILDRL
90
HSLQINSSLS
100
TYSLVDSVGN
110
TKTFDVEHSH
120
VRFLGNLVLN
130
LWDCGGQDTF
140
MENYFTSQRD
150
NIFRNVEVLI
160
YVFDVESREL
170
EKDMHYYQSC
180
LEAILQNSPD
190
AKIFCLVHKM
200
DLVQEDQRDL
210
IFKEREEDLR
220
RLSRPLECSC
230
FRTSIWDETL
240
YKAWSSIVYQ
250
LIPNVQQLEM
260
NLRNFAEIIE
270
ADEVLLFERA
280
TFLVISHYQC
290
KEQRDAHRFE
300
KISNIIKQFK
310
LSCSKLAASF
320
QSMEVRNSNF
330
AAFIDIFTSN
340
TYVMVVMSDP
350
SIPSAATLIN
360
IRNARKHFEK
370
LERVDGPKQC
LLMR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1990131 | Gtr1-Gtr2 GTPase complex |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0051020 | GTPase binding |
| Biological Process | GO:0071230 | cellular response to amino acid stimulus |
| Biological Process | GO:1990253 | cellular response to leucine starvation |
| Biological Process | GO:0009267 | cellular response to starvation |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0010507 | negative regulation of autophagy |
| Biological Process | GO:1904263 | positive regulation of TORC1 signaling |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.