Overview
| Uniprot ID | I3LK71 |
|---|
| Protein Name | - |
|---|
| Gene Name | HNRNPC |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 170 |
GNTSRRGKSGFNSKS |
| 176 |
GKSGFNSKSGQRGSS |
| 190 |
SSKSGKLKGDDLQAI |
| 199 |
DDLQAIKKELTQIKQ |
| 205 |
KKELTQIKQKVDSLL |
| 244 |
EQSSSSQKKDETNVK |
| 30 |
LNTLVVKKSDVEAIF |
| 39 |
DVEAIFSKYGKIVGC |
| 42 |
AIFSKYGKIVGCSVH |
| 50 |
IVGCSVHKGFAFVQY |
| 8 |
MASNVTNKTDPRSMN |
Function
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing
Protein Sequence
10
MASNVTNKTD
20
PRSMNSRVFI
30
GNLNTLVVKK
40
SDVEAIFSKY
50
GKIVGCSVHK
60
GFAFVQYVNE
70
RNARAAVAGE
80
DGRMIAGQVL
90
DINLAAEPKV
100
NRGKAGVKRS
110
AAEMYGSVPE
120
HPSPSPLLSS
130
SFDLDYDFQR
140
DYYDRMYSYP
150
ARVPPPPPIA
160
RAVVPSKRQR
170
VSGNTSRRGK
180
SGFNSKSGQR
190
GSSSKSGKLK
200
GDDLQAIKKE
210
LTQIKQKVDS
220
LLESLEKIEK
230
EQSKQGVEMK
240
NDKSEEEQSS
250
SSQKKDETNV
260
KMESEGGADD
270
SAEEGDLLDD
280
DDNEDRGDDQ
290
LELIKDDEKE
300
AEEGEDDRDS
ANGEDDS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0045120 |
pronucleus |
| Cellular Component |
GO:1990904 |
ribonucleoprotein complex |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.