Overview
| Uniprot ID | I3LKI5 |
|---|
| Protein Name | 7-dehydrocholesterol reductase |
|---|
| Gene Name | DHCR7 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 454 |
DEHRCANKYGRDWER |
| 88 |
RLSDIWAKTPPVTRT |
Function
Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation
Protein Sequence
10
MAAKSQPGTP
20
KTKSLGSVSN
30
GSAATQGQWG
40
RAWEVDWFSL
50
ASVIFLLLCA
60
PFIVYYFIMA
70
CDQYGCSLTA
80
PLGDIATGRA
90
RLSDIWAKTP
100
PVTRTAAQLY
110
TAWVTFQVLL
120
YMLLPDFCHK
130
FLPGYVGGVQ
140
EGAVTPAGVV
150
NKYQINGLQA
160
WLITHLLWFA
170
NSHVLSWFSP
180
TIIFDNWIPL
190
LWCANILGYA
200
VSTFAMIKGY
210
CFPTDARDCK
220
FTGNFFYNYM
230
MGIEFNPRIG
240
KWFDFKLFFN
250
GRPGIVAWTL
260
INLSFAAKQQ
270
QLYGHVTNSM
280
VLVNVLQAIY
290
VLDFFWNETW
300
YLKTIDICHD
310
HFGWYLGWGD
320
CVWLPYLYTL
330
QGLYLVYHPV
340
QLSTPYAVGV
350
LLLGLLGYYI
360
FRMANHQKDL
370
FRRTDGRCLI
380
WGRKPQVIEC
390
SYTSADGQKH
400
HSKLLVSGFW
410
GVARHFNYTG
420
DLLGSLAYCL
430
ACGGGHLLPY
440
FYIIYMGILL
450
THRCLRDEHR
460
CANKYGRDWE
470
RYTATVPYRL
LPGVF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005640 |
nuclear outer membrane |
| Molecular Function |
GO:0047598 |
7-dehydrocholesterol reductase activity |
| Molecular Function |
GO:0033963 |
cholesterol-5,6-oxide hydrolase activity |
| Biological Process |
GO:0006695 |
cholesterol biosynthetic process |
| Biological Process |
GO:0033490 |
cholesterol biosynthetic process via lathosterol |
| Biological Process |
GO:0160020 |
positive regulation of ferroptosis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.