Search Results

Overview

Uniprot IDI3LKJ6
Protein NameElongation factor G, mitochondrial
Gene NameGFM1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
382 RNYQGELKKGDTIYN
504 GCPCITGKPKVAFRE

Function

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis

Protein Sequence

10 MRLLGAAAAA 20 AAVGRGPLPR 30 IPAALGWPGK 40 QANWKICRWC 50 SSGVIPNEKI 60 RNIGISAHID 70 SGKTTLTERV 80 LYYTGRIAKM 90 HEVKGKDGVG 100 AVMDSMELER 110 QRGITIQSAA 120 TYTLWKDVNI 130 NIIDTPGHVD 140 FTIEVERALR 150 VLDGAILVLC 160 AVGGVQCQTM 170 TVNRQMQRYS 180 VPFLTFINKL 190 DRMGSNPTRA 200 LQQMRSKLNH 210 NAALVQIPIG 220 LEGDFKGIID 230 LIEERAIYFD 240 GDFGQIVRYG 250 EIPAEFRAAA 260 SDHRQELIES 270 VANSDEQLGE 280 MFLEEKIPSA 290 SDLKLAIRRA 300 TINRSFTPVF 310 LGSALKNKGV 320 QPLLDAVVEY 330 LPNPSEVQNY 340 AILNQDDSQE 350 KTKILMNSKR 360 DDSHPFVGLA 370 FKLEAGRFGQ 380 LTYVRNYQGE 390 LKKGDTIYNT 400 RTRKKVRVQR 410 LVRMHADMME 420 DVEEVFAGDI 430 CALFGIDCAS 440 GDTFTNKENS 450 GLSMNDLEKF 460 SKGIGRFTRE 470 DPTFKVHFDT 480 ESKETIVSGM 490 GELHLEIYAQ 500 RMEREYGCPC 510 ITGKPKVAFR 520 ETITAPVPFE 530 FTHKKQSGGA 540 GQFGKVIGVL 550 EPLDPENYTK 560 LEFSDETFGA 570 NVPKQFVPAV 580 EKGFLDACEK 590 GPLSGHKLSG 600 LRFVLQDGAH 610 HMVDSNEISF 620 IRAGEGALKQ 630 ALANATVCIL 640 EPIMSVEVIA 650 PNEFQGPVIA 660 GINRRHGVIT 670 GQDGVEDYFT 680 VYAEVPLNDM 690 FGYSTELRSC 700 TEGKGEYTME 710 YCRYQPCSPA 720 TQEDLVNKYL 730 EATGQLPVKK GKAKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0070125 mitochondrial translational elongation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.