Search Results
Overview
| Uniprot ID | I3LKW5 |
|---|---|
| Protein Name | Pre-mRNA-splicing factor RBM22 |
| Gene Name | RBM22 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 206 | GVRMRFKKTEVCQTC |
| 440 | NGRRLNVKWGRSQAA |
Function
Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses
Protein Sequence
10
MATSLGSNTY
20
NRQNWEDAVS
30
VPALPEGGGR
40
RRRGQAVGGR
50
AGTRLRRGPG
60
NLREKPRCGL
70
AWPRLEAGGP
80
PFCGLDRESS
90
ARLQDQPVPL
100
SARGPFSWPR
110
RKCRQRPSRG
120
PARPALDLGF
130
LPCSPALLLA
140
RPPAAPLWPR
150
WQGLRSLAFN
160
QIPLFHQDFP
170
ILCQTCLGEN
180
PYIRMTKEKY
190
GKECKICARP
200
FTVFRWCPGV
210
RMRFKKTEVC
220
QTCSKLKNVC
230
QTCLLDLEYG
240
LPIQVRDAGL
250
SFKDDMPKSD
260
VNKEYYTQNM
270
EREISNSDGT
280
RPVGMLGKAT
290
STSDMLLKLA
300
RTTPYYKRNR
310
PHICSFWVKG
320
ECKRGEECPY
330
RHEKPTDPDD
340
PLADQNIKDR
350
YYGINDPVAD
360
KLLKRASTMP
370
RLDPPEDKTI
380
TTLYVGGLGD
390
TIAETDLRNH
400
FYQFGEIRTV
410
TVVQRQQCAF
420
IQFATRQAAE
430
VAAEKSFNKL
440
IVNGRRLNVK
450
WGRSQAARGK
460
EKEKDGTTDS
470
GIKLEPVPGL
480
PGALPPPPAA
490
EEEASANYFN
500
LPPSGPPAVV
510
NIALPPPPGI
520
APPPPPGFGP
530
HMFHPMGPPP
540
PFMRAPGPIH
550
YPSQDPQRMG
AHAGKHGSP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000974 | Prp19 complex |
| Cellular Component | GO:0071006 | U2-type catalytic step 1 spliceosome |
| Cellular Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0036002 | pre-mRNA binding |
| Molecular Function | GO:0017070 | U6 snRNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071466 | cellular response to xenobiotic stimulus |
| Biological Process | GO:0045292 | mRNA cis splicing, via spliceosome |
| Biological Process | GO:0046827 | positive regulation of protein export from nucleus |
| Biological Process | GO:0042307 | positive regulation of protein import into nucleus |
| Biological Process | GO:0033120 | positive regulation of RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.