Search Results

Overview

Uniprot IDI3LLA8
Protein NameFACT complex subunit SSRP1
Gene NameSSRP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
243 RLFLLPHKDQRQMFF
320 MKALVNRKITVPGNF
359 RGFIYVHKPPVHIRF
58 VALGHGLKLLTKNGH
85 EKLSDFFKTHYRLEL

Function

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II

Protein Sequence

10 MVVPVHLGLF 20 SQQNDGRLRL 30 SRQGIIFKNS 40 KTGKVDNIQA 50 GELTEGIWRR 60 VALGHGLKLL 70 TKNGHVYKYD 80 GFRESEFEKL 90 SDFFKTHYRL 100 ELMEKDLCVK 110 GWNWGTVKFG 120 GQLLSFDIGD 130 QPVFEIPLSN 140 VSQCTTGKNE 150 VTLEFHQNDD 160 AEVSLMEVRF 170 YVPPTQEDGV 180 DPVEAFAQNV 190 LSKADVIQAT 200 GDAICIFREL 210 QCLTPRGRYD 220 IRIYPTFLHL 230 HGKTFDYKIP 240 YTTVLRLFLL 250 PHKDQRQMFF 260 VISLDPPIKQ 270 GQTRYHFLIL 280 LFSKDEDISL 290 TLNMNEEEVE 300 KRFEGRLTKN 310 MSGSLYEMVS 320 RVMKALVNRK 330 ITVPGNFQGH 340 SGAQCITCSY 350 KASSGLLYPL 360 ERGFIYVHKP 370 PVHIRFDEIS 380 FVNFARGTTT 390 TRSFDFEIET 400 KQGTQYTFSS 410 IEREEYGKLF 420 DFVNAKKLNI 430 KNRGLKEGMN 440 PSYDEYADSD 450 EDQHDAYLER 460 MKEEGKIREE 470 NANDSSDDSG 480 EETDESFNPG 490 EEEEDVAEEF 500 DSNASASSSS 510 NEGDSDRDEK 520 KRKQLKKAKM 530 AKDRKSRKKP 540 TEVKKGKDPN 550 APKRPMSAYM 560 LWLNASREKI 570 KSDHPGISIT 580 DLSKKAGEIW 590 KGMSKEKKEE 600 WDRKAEDARR 610 EYEKAMKEYE 620 GGRGESSKRD 630 KSKKKKKVKV 640 KMEKKSTPSR 650 GSSSKSSSRQ 660 LSESFKSKEF 670 VSSDESSSGE 680 NKSKKKRRRS 690 EDSEEEDLAS 700 TPPSSEDSGS ASDE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035101 FACT complex
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0031491 nucleosome binding
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006337 nucleosome disassembly
Biological Process GO:1902275 regulation of chromatin organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.