Search Results
Overview
| Uniprot ID | I3LLG4 |
|---|---|
| Protein Name | DnaJ homolog subfamily A member 3, mitochondrial |
| Gene Name | DNAJA3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 168 | KAYYQLAKKYHPDTN |
Function
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway
Protein Sequence
10
MGFGRARATL
20
VFLLASAAGP
30
APGSTGAARV
40
RRPGAAARSR
50
AAQAQCPRAK
60
MAARCSPRLL
70
LVAVGTPWLP
80
TAARRGARPP
90
LGGAVGASLG
100
RNLSVTAFAS
110
SLGARGARAL
120
LTLRPGVSLT
130
GVKSSPSVCT
140
AFFHTSATLS
150
KEDYYQILGV
160
PRSASQKEIK
170
KAYYQLAKKY
180
HPDTNKDDPK
190
AKEKFSQLAE
200
AYEVLSDEVK
210
RKQYDTYGSA
220
GFDAGAGGSG
230
QGYWKGGPTV
240
DPEELFRKIF
250
GEFSSSPFGD
260
FQGVFNQPQE
270
YIMELTFNQA
280
AKGVNKEFTV
290
NMTDTCERCD
300
GKGNEPGTKL
310
QHCHYCGGSG
320
METINTGPFV
330
MRSTCRRCGG
340
RGSIITSPCV
350
VCRGTGQAKQ
360
KKKVMIPVPA
370
GVEDGQTVRM
380
PVGKREIFIT
390
FRVQKSPVFR
400
RDGADIHSDL
410
FISIAQALLG
420
GTARAQGLYE
430
TINVTIPAGI
440
QTDQKIRLSG
450
KGIPRINSYG
460
YGDHYIHVKI
470
RVPRRLTSRQ
480
QSLILSYAED
490
ETDVEGTVNG
500
VTNTSTGKRS
TGN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0002682 | regulation of immune system process |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0002376 | immune system process |
| Biological Process | GO:0043069 | negative regulation of programmed cell death |
| Biological Process | GO:0007528 | neuromuscular junction development |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:0009408 | response to heat |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.