Search Results

Overview

Uniprot ID	I3LLW7
Protein Name	-
Gene Name	LOC100626015
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
584	VNRFCLSKPGVYKVT
589	LSKPGVYKVTPRSCH

Function

Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions

Protein Sequence

10 MGGCRGVRPP 20 GPVVVAATVM 30 VLLSCVGPAR 40 GSEDIVVGCG 50 GFVKSDVEIN 60 YSLIEIKLYT 70 KHGTLKYQTD 80 CAPNNGYFMI 90 PLYDKGDFIL 100 KIEPPLGWSF 110 EPTTVELYVD 120 GVSDICTKGG 130 DINFVFTGFS 140 VNGKVLSKGQ 150 PLGPAGVQVS 160 LRSTGTDAKI 170 QSTVTQPGGK 180 FAFFKVLPGD 190 YEILATHPTW 200 ALKEASTTVR 210 VTNSNANAAG 220 PLIVAGYNVS 230 GSVRSDGEPM 240 KGVKFLLFSS 250 SVSKEIPFYR 260 GERITFDVAP 270 SRLDFTVEHD 280 SLKIEPVFHV 290 MGFSVTGRVL 300 NGPEGEGVPD 310 AVVTLNNQIK 320 VRTKADGSFR 330 LENITTGTYT 340 IHAQKEHLYF 350 ETVTIKIAPN 360 TPQLADIIAT 370 GFSVCGQISI 380 LRFPDTVKQM 390 SKYKVVLSSQ 400 DKDKSLVTVE 410 TDAQGSFCFK 420 AKPGTYKVQV 430 MVPEVETRAG 440 LTLKPQTLLL 450 AVTDRPVMDV 460 AFVQFLASVS 470 GKVSCLDTCG 480 DLLVTLQSLS 490 RQGEKRSLQL 500 SGKLNSMTFT 510 FDNVLPGKYK 520 TSIMHEDWCW 530 KNKSLEVEVL 540 EEDVSAVEFR 550 QTGYMLRCSL 560 SHAITLEFYQ 570 DGNGPENVGI 580 YNLSKGVNRF 590 CLSKPGVYKV 600 TPRSCHRFEQ 610 AFYTYDTSSP 620 SILTLTAIRH 630 HVLGTITTDK 640 MMDVTVTIKS 650 SIDSEPALVL 660 GPLKSVQELR 670 REQQLAEIES 680 RRQEREKNGG 690 EEGGEGGTKP 700 PVQEMVDELQ 710 GPFSYDFSYW 720 ARSGEKITVT 730 PSSKELLFYP 740 PSMEATVSGE 750 SCPGKLIEIQ 760 GKAGLFLEGQ 770 IHPELEGVEI 780 VISEKGASSP 790 LITVFTDDKG 800 AYSVGPLHSD 810 LEYTVSSQKE 820 GYVLTAVEGT 830 IGDFKAYALA 840 GVSFEIKAED 850 DQPLPGVLLS 860 LSGGVFRSNL 870 LTQDNGILTF 880 SNLSPGQYYF 890 KPMMKEFRFE 900 PSSQMIEVQE 910 GQNLKITITG 920 YRTAYSCYGT 930 VSSLNGEPEQ 940 GVAVEAVGQN 950 DCSIYGEDTV 960 TDEEGKFRLR 970 GLLPGCVYHV 980 QLKAEGNDHI 990 ERALPHHRVI 1000 TVGNNDIDDV 1010 NIIVFRQINQ 1020 FDLSGNVITS 1030 SEYLPTLWVK 1040 LYKSDNLDNP 1050 IQTVSLGQSL 1060 FFHFPPLLRD 1070 GQNYVVLLDS 1080 TLPKSQYDYV 1090 LPQVTFTAAG 1100 YHKHITLIFN 1110 PARKLPEQDI 1120 AQGSYIALPL 1130 TLLVLLAGYN 1140 HDKLIPLLLQ 1150 LTSRLQGVRA 1160 LGQTASDGSG 1170 PEDAKRQAKK QKTRRT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0160064	multi-pass translocon complex
Molecular Function	GO:0030246	carbohydrate binding
Molecular Function	GO:0043022	ribosome binding
Biological Process	GO:0160063	multi-pass transmembrane protein insertion into ER membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.