Overview
| Uniprot ID | I3LLY2 |
|---|
| Protein Name | Glycerophosphodiester phosphodiesterase 1 |
|---|
| Gene Name | GDE1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 287 |
FVSPAYLKKWSAKGI |
Function
Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol. Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity. Has little or no activity towards glycerophosphocholine
Protein Sequence
10
MWVWEEQGGL
20
MGPFSFLLLL
30
LLLLTRSPFN
40
ACLFTGSLYL
50
LLRLFSFEPV
60
PSRRAVQVLK
70
PRDRVSAIAH
80
RGGSYDAPEN
90
TLAAIRQAAK
100
NGAAGVELDI
110
EFTSDGIPVL
120
MHDNTVDRTT
130
DGTGRLCDLT
140
FEQIRKLNPA
150
ANHRLRNDFP
160
DEKIPTLREA
170
VAECLRHNLT
180
VFFDVKGHAN
190
MATDALKKIY
200
MEFPQLYNNS
210
IVCSFLPEVI
220
YKMRQADQNV
230
LTALIHRPWS
240
LSHTGDGKPR
250
FDTFWKQSTF
260
VALDILLDWS
270
MHNILWYLCG
280
ISAFLIQKDF
290
VSPAYLKKWS
300
AKGIQVVAWT
310
VNTFDEKSYY
320
ESHLGSSYIT
330
DSMLEDCSPQ
F
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030659 |
cytoplasmic vesicle membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0008889 |
glycerophosphodiester phosphodiesterase activity |
| Molecular Function |
GO:0047395 |
glycerophosphoinositol glycerophosphodiesterase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0004622 |
phosphatidylcholine lysophospholipase A1 activity |
| Biological Process |
GO:0006580 |
ethanolamine metabolic process |
| Biological Process |
GO:0070291 |
N-acylethanolamine metabolic process |
| Biological Process |
GO:0006644 |
phospholipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.