Search Results
Overview
| Uniprot ID | I3LN50 |
|---|---|
| Protein Name | Translation initiation factor eIF2B subunit gamma |
| Gene Name | EIF2B3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 150 | VGVDSTGKRLLFMAN |
Function
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed
Protein Sequence
10
MTDLTSSVPK
20
PLLPVGNKPL
30
IWYPLNLLER
40
VGFEEVIVIT
50
TRDVQKALCA
60
DFKMKMKLDI
70
VCIADDADIG
80
TADSLRYIYQ
90
KLKTDVLVLS
100
CDLITDVALH
110
EVVDLFRAHD
120
ATLAMLMRKG
130
QDGLESVPGQ
140
KGKKKAVEQR
150
DFVGVDSTGK
160
RLLFMANEAD
170
LDEELVIKGA
180
ILQKHPRIRF
190
HTGLVDAHLY
200
CLRRYVVDFL
210
MEYKSITSIR
220
SELIPYLVRK
230
QFSSASSQQG
240
QEEKEEELKK
250
KELKTLDIYS
260
FIKEVGPLTF
270
ALHDACWNAC
280
RGDSREDLSR
290
SQVRCYVHIM
300
KEGLCSRVGT
310
LGLYMEANRQ
320
VSKLLPVICP
330
EETLVHPSAQ
340
IVSKHLIGAD
350
SLIGPDTQVG
360
EKSSVKRSVI
370
GSSCVIRDRV
380
TVTNSLLMNS
390
VTVEEGQTSE
400
RSSRGERPSH
410
GDLSSEQVTL
420
LPLGPGTAGV
430
GWPTSLILYL
440
FPNKRRAPRG
450
VLETCGRVPS
460
SASGGLWGYT
470
ACVRVVKTSG
480
ARVRNRQGRG
VH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005851 | eukaryotic translation initiation factor 2B complex |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0008135 | translation factor activity, RNA binding |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Biological Process | GO:0002183 | cytoplasmic translational initiation |
| Biological Process | GO:0014003 | oligodendrocyte development |
| Biological Process | GO:0045948 | positive regulation of translational initiation |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.