Search Results

Overview

Uniprot ID	I3LNB4
Protein Name	Multifunctional fusion protein
Gene Name	ALDH4A1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
136	SPFNHGHKVAKFCYA
145	AKFCYADKALLHRAI
160	EAALAARKEWDLKPV
364	LAGECGGKNFHFVHR

Function

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes

Protein Sequence

10 MTKDTRWQDL 20 NLNLGFGLRG 30 WFSSPCSIVA 40 LDFKIPGQSR 50 TPVRNRGWDW 60 RWLLLTCPPL 70 FLPLVPRLCW 80 KHISSLEVAN 90 EPVLTFTQGS 100 PERDALRKAL 110 KELKGRTEAI 120 PCVVGDEEVW 130 TSDVRYQVSP 140 FNHGHKVAKF 150 CYADKALLHR 160 AIEAALAARK 170 EWDLKPVADR 180 AQVFLKAADM 190 LSGPRRAEIL 200 AKTMVGQGKT 210 VIQAEIDAAA 220 ELIDFFRFNA 230 KFAVELEGQQ 240 PISVPPSTNS 250 VVYRGLEGFV 260 AAISPFNFTA 270 IGGNLAGAPA 280 LMGNVVLWKP 290 SDTAMLASYA 300 VYRVLREAGL 310 PPNIIQFVPA 320 DGPTFGDTVT 330 SSEHLCGINF 340 TGSVPTFKHL 350 WKQVAQNLDH 360 FRTFPRLAGE 370 CGGKNFHFVH 380 RSADVDSVVS 390 GTLRSAFEYG 400 GQKCSACSRL 410 YVPGSLWPQI 420 KGRLLEEHGR 430 IKVGDPAEDF 440 GTFFSAVIDA 450 KSFGRIRKWL 460 EHARSSPSLT 470 ILAGGQCDDS 480 VGYFVEPCII 490 ESKDPQEPIM 500 KEEIFGPLLT 510 VYVYPDDKYK 520 ETLRLVDSTT 530 SYGLTGQCLD 540 VVREATEMLR 550 NAAGNFYIND 560 KSTGSVVGQQ 570 PFGGARASGT 580 NDKPGGPHYV 590 LRWTSPQVIK 600 ETHKPLGDWR YPYMQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0003842	L-glutamate gamma-semialdehyde dehydrogenase activity
Biological Process	GO:0010133	L-proline catabolic process to L-glutamate

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.