Search Results

Overview

Uniprot IDI3LNH3
Protein NameNeutral alpha-glucosidase AB
Gene NameGANAB
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
291 HADSLRLKVTEGGDP
39 AVDRSNFKTCEESSF
48 CEESSFCKRQRSIRP
484 HLASKRRKLVAIVDP
513 QNLGLYVKTRDGSDY
921 VVIIGAGKPATVVLQ
930 ATVVLQTKGSPESRL

Function

Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia

Protein Sequence

10 MAAVAAVAAR 20 RRRSWTGLVL 30 ACLGVCLGLT 40 LAVDRSNFKT 50 CEESSFCKRQ 60 RSIRPGQSPY 70 RALLDSLQLG 80 PDTLTIHLIN 90 EVTKVLLVLE 100 LQGLQKNMTR 110 IRIDELEPRR 120 PRYRVPDVLV 130 AEPPTARLSV 140 SGQDDNSVEV 150 TVAEGPYKII 160 LTARPFRLDL 170 LEDRSLLLSV 180 NARGLLNFEH 190 QRAPRVSFSD 200 KVSLTLGSIW 210 DKIKNLFSRQ 220 GSKDPAEGDG 230 AQPEEAPGDG 240 DKPEEIQGKA 250 EKDEPGAWEE 260 TFKTHSDSKP 270 YGPTSVGLDF 280 SLPGMEHVYG 290 IPEHADSLRL 300 KVTEGGDPYR 310 LYNLDVFQYE 320 LYNPMALYGS 330 VPVLLAHSPH 340 RDLGIFWLNA 350 AETWVDISSN 360 TAGKTLFGKM 370 LDYLQGSGET 380 PQTDVRWMSE 390 SGIIDVFLLL 400 GPSVFDVFRQ 410 YASLTGTQAL 420 PPLFSLGYHQ 430 SRWNYRDEAD 440 VLEVNQGFDD 450 HNLPCDFIWL 460 DIEHADGKRY 470 FTWDPSRFPQ 480 PRTMLEHLAS 490 KRRKLVAIVD 500 PHIKVDSSYR 510 VHEELQNLGL 520 YVKTRDGSDY 530 EGWCWPGAAS 540 YPDFTNPKMR 550 AWWADMFRFE 560 NYEGSSSNLY 570 VWNDMNEPSV 580 FNGPEVTMLK 590 DAQHYGGWEH 600 RDLHNIYGFY 610 VHMATADGLV 620 LRSGGVERPF 630 VLSRAFFAGS 640 QRFGAVWTGD 650 NTAEWDHLKI 660 SIPMCLSLGL 670 VGLSFCGADV 680 GGFFKNPEPE 690 LLVRWYQMGA 700 YQPFFRAHAH 710 LDTGRREPWL 720 LPTQYQDMIR 730 DALGQRYSLL 740 PFWYTLFYQA 750 HREGVPVMRA 760 LWVHYPQDVT 770 TFSIDDEFLL 780 GDALLVHPVT 790 DSEAHGVQVY 800 LPGQGEVWYD 810 VHSYQKYHGP 820 QTLYLPVTLS 830 SIPVFQRGGT 840 IVPRWMRVRR 850 SSDCMKDDPI 860 TLFVALSPQG 870 TAQGELFLDD 880 GHTFNYQTGH 890 EFLLRRFSFS 900 GNTLVSSSAD 910 SKGHFETPVW 920 IERVVIIGAG 930 KPATVVLQTK 940 GSPESRLSFQ 950 HDPETSVLIL 960 RKPGVNVASD WSIHLR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017177 glucosidase II complex
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0042470 melanosome
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0106407 Glc2Man9GlcNAc2 oligosaccharide glucosidase activity
Molecular Function GO:0033919 glucan 1,3-alpha-glucosidase activity
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0006491 N-glycan processing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.