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Overview

Uniprot IDI3LNN6
Protein NameKinesin-like protein
Gene NameKIF22
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
27 AGRCRLSKVGAGRRP

Function

Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells

Protein Sequence

10 MDAGLPARRR 20 REMAAATSGA 30 GRCRLSKVGA 40 GRRPPPARVR 50 VAVRLRPFVD 60 GTAGENDPPC 70 VRGLDSCSLE 80 IANWRNHQET 90 LKYQFDAFYG 100 ERSSQQDVYG 110 GSVQPILRHL 120 LEGQNASVLA 130 YGPTGAGKTH 140 TMLGSPEQPG 150 VIPRALMDLL 160 QLTREEGAEG 170 RPWALSVTMS 180 YLEIYQEKVL 190 DLLEPSSGDL 200 VIREDCRGNI 210 LIPGLTQKPI 220 TSFADFEQHF 230 LPASRNRTVG 240 ATRLNQRSSR 250 SHAVLLVKVD 260 QRERLAPFRQ 270 REGKLYLIDL 280 AGSEDNRRTG 290 NKGLRLKESG 300 AINASLFVLG 310 KVVDALNQGL 320 PRVPYRDSKL 330 TRLLQDSLGG 340 SAHSILIANI 350 APERRFYLDT 360 VSALNFAARS 370 KEVINRPFTN 380 ERLQLHVLAP 390 IKLSQKELLG 400 PSEAKRARGP 410 EEEESGSPEP 420 PAAPASAFQK 430 LSPLQKLSSM 440 DPAMLERLLS 450 LDRLLGSQGS 460 QGTPLLSTPK 470 RERMVLMKTV 480 EEKDLEIERL 490 KMKQKELEAK 500 VLAQEAADPK 510 EKENYSPTTL 520 RPLARRTVTV 530 AKPLKRAVVM 540 PLQLIQEQAA 550 SPNAEIHILK 560 KKGRKRKLES 570 LDASEPEEKA 580 EDCWELQISP 590 ELLAHGRQKI 600 LDLLNEGSAR 610 DLRSLQRIGQ 620 KKAQLIVGWR 630 ELHGPFSQVE 640 DLERVEGISS 650 KQMESFLKAN 660 ILGLAAGQRC GPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005871 kinesin complex
Cellular Component GO:0005874 microtubule
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0016607 nuclear speck
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Biological Process GO:0006281 DNA repair
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0007080 mitotic metaphase chromosome alignment
Biological Process GO:0007062 sister chromatid cohesion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.