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Overview

Uniprot IDI3LP37
Protein NameTrifunctional purine biosynthetic protein adenosine-3
Gene NameGART
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
156 ASGLAAGKGVIIAES
28 LAQSNHVKQVLVTPG

Function

Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway

Protein Sequence

10 MAAQVLVIGN 20 GGREHTLAWK 30 LAQSNHVKQV 40 LVTPGNAGTA 50 SSEKISNTDV 60 SVSDHAALAQ 70 FCKEEKIEFV 80 VVGPEAPLAA 90 GIVGNLTSAG 100 VRCFGPTAEA 110 AQLESSKRFA 120 KEFMDRHGIP 130 TAQWRAFTKP 140 EEACSFIMSA 150 DFPALVVKAS 160 GLAAGKGVII 170 AESKEEACKA 180 VQEIMQDRAF 190 GEAGETIVIE 200 ELLEGEEVSC 210 LCFTDGRTVA 220 PMPPAQDHKR 230 LLDGDHGPNT 240 GGMGAYCPAP 250 QVSKDLLLKI 260 KDTILQKTVA 270 GMQQEGVPYT 280 GILYAGIMLT 290 KNGPKVLEFN 300 CRFGDPECQV 310 ILPLLKSDLY 320 EVIQATLDGR 330 LCTSLPVWHD 340 NRAAVTVVMA 350 SKGYPGDYTK 360 GVEITGFHEA 370 QALGLEVFQA 380 GTALKDGKVV 390 TNGGRVLTVT 400 AIQENLISAL 410 EEAKKGLAAI 420 KFEGAIYRKD 430 IGCRAIAFLQ 440 QPRGLTYKES 450 GVDIAAGNML 460 VKKIKPLAKA 470 TSRPGCDVDL 480 GGFAGLFDLK 490 AAGFSDPLLA 500 CGTDGVGTKL 510 KIAQQCHKHD 520 TIGQDLVAMC 530 VNDILAQGAE 540 PLFFLDYFSC 550 GKLDLNTTEA 560 VVAGIAEACK 570 KAGCALLEMP 580 DMYPPGEYDL 590 AGFAVGAMER 600 DQKLPHLERI 610 TEGDAVIGVA 620 SSGLHSNGFS 630 LVRKIIAKSS 640 LQYSSPAPDG 650 CGDQTLGDLL 660 LTPTRIYSHS 670 LLPVLRSGHV 680 KAFAHITGGG 690 LLENIPRVLP 700 QKFGVDLDAR 710 TWRIPRIFSW 720 LQQLGHLSEE 730 EMARTFNCGI 740 GAALVVSKDL 750 TEQILQDIER 760 HKEEAWVIGK 770 VVACPEGSPR 780 VKVKHLIESM 790 QINGSVLENG 800 TLKNHFSVQP 810 KKARVAVLIS 820 GTGSNLQALI 830 ESTQAPSSSA 840 HIIVVISNKA 850 AVAGLDKAAR 860 AGIPTRVINH 870 KLYKDRVAFD 880 MAVDQVLEEF 890 STDIVCLAGF 900 MRILSGPFVR 910 KWNGKMLNIH 920 PSLLPSFKGS 930 NAHEQVLDAG 940 VTVTGCTVHF 950 VAEDVDAGQI 960 VLQEAVPVKR 970 GDTIETLSER 980 VKLAEHKIFP 990 SALQLVASGT 1000 VQLGENGKIR WVREE

Gene Ontology

Classification GO ID Description
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004637 phosphoribosylamine-glycine ligase activity
Molecular Function GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
Molecular Function GO:0004644 phosphoribosylglycinamide formyltransferase activity
Biological Process GO:0044208 'de novo' AMP biosynthetic process
Biological Process GO:0006189 'de novo' IMP biosynthetic process
Biological Process GO:0097294 'de novo' XMP biosynthetic process
Biological Process GO:0006177 GMP biosynthetic process
Biological Process GO:0009113 purine nucleobase biosynthetic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.