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Overview

Uniprot IDI3LPF1
Protein NameGolgi resident protein GCP60
Gene NameACBD3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
111 PTYEEKLKLVALHKQ

Function

Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase

Protein Sequence

10 MAAVLNAERL 20 EVSVDGLTLS 30 PDPEERPGAE 40 GAPLLPPPLP 50 PPSPPGSDRG 60 RGAAGEQPEP 70 GEAAAGGAAE 80 EARRLEQRWG 90 FGLEELYGLA 100 LRFFKEKDGK 110 AFHPTYEEKL 120 KLVALHKQVL 130 MGPYNPDTCP 140 EVGFFDVLGN 150 DRRREWAALG 160 TMSKEDAMVE 170 FVKLLNRCCH 180 LFSTYVASHK 190 IEKEEQEKKR 200 KEEEERRRRE 210 EEERERLQKE 220 EEKRRREEEE 230 RLRREEEERR 240 RIEEERLRLE 250 QQKQQIMAAL 260 NSQTAVQFQQ 270 YAAQQYPGNY 280 EQQQILIRQL 290 QEQHYQQYMQ 300 QLYQVQLAQQ 310 QAALQKQQEV 320 AVAGASLPTS 330 SKVNTPAPGD 340 MMSVNGQAKN 350 HSDNSEKELE 360 PETAEEALEN 370 GPKESLPVIA 380 APSMWTRPQI 390 RDFKEKIRQD 400 SDSVITVGRG 410 EVVTVRVPTH 420 EEGSYLFWEF 430 ATDNYDIGFG 440 VYFEWTDSPN 450 TAVSVHVSES 460 SDDDDEEEEN 470 ISSEEKAKKN 480 ANKPVLDEIV 490 PVYRRDCHEE 500 VYAGSHQYPG 510 RGVYLLKFDN 520 SYSLWRSKSV YYRVYYTR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0000062 fatty-acyl-CoA binding
Molecular Function GO:0034237 protein kinase A regulatory subunit binding
Biological Process GO:0006694 steroid biosynthetic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.