Overview
| Uniprot ID | I3LPH5 |
|---|
| Protein Name | Ras GTPase-activating protein-binding protein 2 |
|---|
| Gene Name | G3BP2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 364 |
VELRINTKGVGGKLP |
Function
Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations
Protein Sequence
10
MVMEKPSPLL
20
VGREFVRQYY
30
TLLNKAPEYL
40
HRFYGRNSSY
50
VHGGVDASGK
60
PQEAVYGQND
70
IHHKVLSLNF
80
SECHTKIRHV
90
DAHATLSDGV
100
VVQVMGLLSN
110
SGQPERKFMQ
120
TFVLAPEGSV
130
PNKFYVHNDM
140
FRYEDEVFGD
150
SEPELDEESE
160
DEVEEEQEER
170
QPTPEPVQET
180
NSGYYEAHPV
190
TNGIEEPLEE
200
SSHEPEPEPE
210
SETKTEELKP
220
QVEEKNLEEL
230
EEKSTSPPPA
240
EPVSLPQEPP
250
KAFSWASVTS
260
KNLPPSGTVS
270
SSGIPPHVKA
280
PVSQPRVETK
290
PEVQSQPPRV
300
REQRPRERPG
310
FPPRGPRPGR
320
GDIEQNESDN
330
RRIIRYPDSH
340
QLFVGNLPHD
350
IDENELKEFF
360
MSFGNVVELR
370
INTKGVGGKL
380
PNFGFVVFDD
390
SEPVQRILIA
400
KPIMFRGEVR
410
LNVEEKKTRA
420
ARERETRGGG
430
DDRRDIRRND
440
RGPGGPRGVV
450
GGGMMRDRDG
460
RGPPPRGGMA
470
QKLGSGRGTG
480
QMEGRFTGQR
R
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0010494 |
cytoplasmic stress granule |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0140693 |
molecular condensate scaffold activity |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0051028 |
mRNA transport |
| Biological Process |
GO:0051260 |
protein homooligomerization |
| Biological Process |
GO:0034063 |
stress granule assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.