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Overview

Uniprot IDI3LPP4
Protein NameExportin-2
Gene NameCSE1L
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
19 TLTEYLKKTLDPDPT
427 KNPSVNWKHKDAAIY
429 PSVNWKHKDAAIYLV
609 QKLLAVSKNPSKPHF
834 IIIPEIQKVSGNVEK
841 KVSGNVEKKICAVGI
842 VSGNVEKKICAVGIT
85 IVEDEPNKICEADRV
936 HLAQSLHKLSTACPG

Function

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

Protein Sequence

10 MAMELSDANL 20 QTLTEYLKKT 30 LDPDPTIRRP 40 AEKFLESVEG 50 NQNYPLLLLT 60 LLEKSQDNVI 70 KVCASVTFKN 80 YIKRNWRIVE 90 DEPNKICEAD 100 RVAIKANIVH 110 LMLSSPEQIQ 120 KQLSDAISII 130 GREDFPQKWP 140 DLLTEMVNRF 150 QSGDFHVING 160 VLRTAHSLFK 170 RYRHEFKSNE 180 LWTEIKLVLD 190 AFALPLTNLF 200 KATIELCSTH 210 ANDASALRIL 220 FSSLILISKL 230 FYSLNFQDLP 240 EFFEDNMETW 250 MNNFHTLLTL 260 DNKLLQTDDE 270 EEAGLLELLK 280 SQICDNAALY 290 AQKYDEEFQR 300 YLPRFVTAIW 310 NLLVTTGQEV 320 KYDLLVSNAI 330 QFLASVCERP 340 HYKNLFEDQN 350 TLTSICEKVI 360 VPNMEFRAAD 370 EEAFEDNSEE 380 YIRRDLEGSD 390 IDTRRRAACD 400 LVRGLCKFFE 410 GPVTGIFSGY 420 VNSMLQEYAK 430 NPSVNWKHKD 440 AAIYLVTSLA 450 SKAQTQKHGI 460 TQANELVNLT 470 EFFVNHILPD 480 LKSANVNEFP 490 VLKADGIKYI 500 MIFRNQVPKE 510 HLLVSIPLLI 520 NHLQAESIVV 530 HTYAAHALER 540 LFTMRGPNNA 550 TLFTAAEIAP 560 FVEILLTNLF 570 KALTLPGSSE 580 NEYIMKAIMR 590 SFSLLQEAII 600 PYIPTLITQL 610 TQKLLAVSKN 620 PSKPHFNHYM 630 FEAICLSIRI 640 TCKANPAAVV 650 NFEEALFLVF 660 TEILQNDVQE 670 FIPYVFQVMS 680 LLLETHKNDI 690 PSSYMALFPH 700 LLQPVLWERT 710 GNIPALVRLL 720 QAFLERGSNT 730 IASAAADKIP 740 GLLGVFQKLI 750 ASKANDHQGF 760 YLLNSIIEHM 770 PPESVDQYRK 780 QIFILLFQRL 790 QNSKTTKFIK 800 SFLVFINLYC 810 IKYGALALQE 820 IFDGIQPKMF 830 GMVLEKIIIP 840 EIQKVSGNVE 850 KKICAVGITK 860 LLTECPPMMD 870 TEYTKLWTPL 880 LQSLIGLFEL 890 PEDDTIPDEE 900 HFIDIEDTPG 910 YQTAFSQLAF 920 AGKKEHDPVG 930 QMVNNPKIHL 940 AQSLHKLSTA 950 CPGRVPSMVS 960 TSLNAEALQY 970 LQGYLQAASV TLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0005049 nuclear export signal receptor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006611 protein export from nucleus

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.