Search Results
Overview
| Uniprot ID | I3LQ79 |
|---|---|
| Protein Name | Major vault protein |
| Gene Name | MVP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 33 | SRVEVGPKTYIRQDN |
| 745 | EGSVLQAKLKAEALA |
Function
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases
Protein Sequence
10
MATEESIIRI
20
PPYHYIHVLD
30
QNSNVSRVEV
40
GPKTYIRQDN
50
ERILFAPVRM
60
VTIPPRHYCT
70
VANPVSRDAQ
80
GSVQCDVTGQ
90
VRLRHADLEI
100
RLAQDPFPLY
110
PGEVLEKDIT
120
PLQVVLPNTA
130
LHLKALLDFE
140
DKNGDKVVAG
150
DEWLFEGPGT
160
YVPRKEVEVV
170
QIIQASVIKQ
180
NQALRLKARK
190
ECWDRDGKER
200
VTGEEWLVRS
210
VGAYLPAVFE
220
EVLDVVNAVI
230
LTEKTALHLR
240
ARQNFRDLRG
250
VVRRTGEEWL
260
VTVQDTEAHV
270
PDVYEEVVGV
280
VAITTLGPHN
290
YCVILDPVGP
300
DGKNQLGQKR
310
VVKGEKSFFL
320
QPGEKLERGI
330
QKVYVLSEQQ
340
GLLLRALQPL
350
EEGEDEEKVS
360
HQAGDRWLIR
370
GPLEYVPSAK
380
VEVVEERQAI
390
PLDENEGIYV
400
QDVKTGRVRA
410
VIGSTYMLTQ
420
DEVLWEKELP
430
PGVEELLLKG
440
QDPLADRGEK
450
DTARSQQPSA
460
PRNKTRVVSY
470
RVPHNAAVQV
480
YDYREKRARV
490
VFGPELVSLG
500
PEEQFTVLSL
510
SAGRPKRPHA
520
RRALCLLLGP
530
DFFTDVITIE
540
TADHARLQLQ
550
LAYNWHFELS
560
DRKDPQEAAR
570
LFSVPDFVGD
580
ACKAIASRVR
590
GAVASVTFDD
600
FHKNSARIIR
610
TAVFGFEIPE
620
TKGPDSTALP
630
QPRDRAVFPQ
640
NGLVVSSVDV
650
QSVEPVDQRT
660
RDALQRSVQL
670
AIEITTNSQE
680
AAAKHEAQRL
690
EQEARGRLER
700
QKILDQAEAE
710
KARRDLLELE
720
ALSTAVESTG
730
TAKAEAESRA
740
EAARIEGEGS
750
VLQAKLKAEA
760
LAIETEAELQ
770
RVKKVRELEL
780
VYARAQLELE
790
VSKAQQLAEV
800
EVKKFRQMTE
810
ALGPSTIRDL
820
AVAGPEMQVK
830
LLQSLGLKST
840
LITDGSTPIN
850
LFNTAFGLLG
860
LGSEAPAPAP
870
APAPAPAPAR
880
KAAGAPITQE
890
GLLPPPTPIP
900
SVLQGNQIVP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0038127 | ERBB signaling pathway |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0072376 | protein activation cascade |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.