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Overview

Uniprot IDI3LQD7
Protein NameCyclin-G-associated kinase
Gene NameGAK
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
97 GQLVEFLKKVESKGP

Function

Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly

Protein Sequence

10 MFPFWTPQST 20 GGFAFVYEAQ 30 DLGSGREYAL 40 KRLLSNEEEK 50 NRVIIQEVCF 60 MKKLSGHPNI 70 VQFCSAASIG 80 KEESDTGQAE 90 FLLLTELCKG 100 QLVEFLKKVE 110 SKGPLSCDTV 120 LKIFYQTCRA 130 VQHMHKQKPP 140 IIHRDLKVEN 150 LLLSNQGTIK 160 LCDFGSATTI 170 SHYPDYSWSA 180 QQRALVEEEI 190 TRNTTPMYRT 200 PEIVDLYSNF 210 PIGEKQDIWA 220 LGCILYLLCF 230 RQHPFEDGAK 240 LRIVNGKYVI 250 PPDDTRYSVF 260 HGLIRATLKV 270 NPEERLSITE 280 LVNQLQEIAA 290 ARNVNPKSPI 300 TELLEQNGGC 310 GSAAPPTGSA 320 SSGCSGGLAV 330 AEYDQPYGGL 340 LDILRGGTER 350 LFTNIKDTSS 360 KVIQSVASYA 370 KGDLDISYIT 380 SRIAVMSFPA 390 EGVESAIKNN 400 VEDVRLFLDS 410 KHPGRYTVYN 420 LSPRTYRPSR 430 FHSRVSECGW 440 VARRAPSLHS 450 LYSLCRSMHA 460 WLRQDPKNVC 470 VVHCMDGRAA 480 SAVAVCSFLC 490 FCRLFSTAEA 500 AVYMFSMKRC 510 PPGIWPSHKR 520 YIEYVCDMVA 530 EEPITPHSKP 540 VLVKAVAMTP 550 VPLFSKQRHG 560 CRPFCEVYVG 570 DERVATTSQE 580 YDKMRDFRVE 590 DGKAVIPLDV 600 AVQGDVLVVI 610 YHARSTLGGR 620 LQAKMASMKM 630 FQIQFHTGFV 640 PRNATTVKFA 650 KYDLDACDIQ 660 EKFPDLFQVH 670 LEVEVEPRDR 680 PSREAPPWES 690 ASMRGLNPKI 700 LFSSREEQQD 710 VLSKFGKPEL 720 PRQPGSTAQY 730 EAEGPGPDLP 740 HSSADANHFL 750 HTLDWQEDRD 760 TTAGPEGHPA 770 KEDPPAAAED 780 GRESEPSDEE 790 ATTLSAESGD 800 TADEDAPGPA 810 APPEDSVDLL 820 GLHAEAGPAP 830 CPQARGGPPS 840 NADLLSCLLG 850 APPPAPAGTT 860 GRLLEGDTSL 870 LFSSPAPPPS 880 APTAPREASA 890 PAADPFDPLL 900 LPSDPVSQPC 910 SRPDLFGEFL 920 TSDSPAGPPA 930 SFPSTHSAPP 940 PACSSDFLRL 950 GDLPTEPSRV 960 TASTSHPDLL 970 GGWDAWAEAS 980 APTSATEGPF 990 FSPGGQPAPP 1000 GPPASQPQSQ 1010 NQDPFADLGD 1020 LSSSLQGSPA 1030 APPPGGFGPK 1040 TGALPKASGS 1050 WQTSRPSAQG 1060 TSWHPQARPP 1070 PKATAQPRPN 1080 YTPGFSVIGS 1090 REERGVRAPG 1100 FGPRPRVSEN 1110 DFEDLLSSQG 1120 FSSRADRRGP 1130 RTVAEMRRQD 1140 QARDTDPLKL 1150 KLQDWTEGKE 1160 RNIRALLSTL 1170 HTVLWDGESR 1180 WTPVGMADLV 1190 TPGQVKKQYR 1200 RAVLVVHPDK 1210 AQGQPYEQHA 1220 RLIFMELSDA 1230 WAEFESQGCR PLF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004674 protein serine/threonine kinase activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.