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Overview

Uniprot ID	I3LQG8
Protein Name	Ubiquitin conjugation factor E4
Gene Name	UBE4B
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1015	KSTIAIEKFKLLAEK

Function

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates

Protein Sequence

10 MTPATSPIGA 20 SGVAHRSQSS 30 EGVSSLSSSP 40 SNSLETQSQS 50 LSRSQSMDID 60 GVSCEKSLSQ 70 VDVDSGIENM 80 EVDENDRREK 90 RSLSDKEPSS 100 GSEVSEEQAL 110 QLVCKILRVS 120 WKDRDRDVIF 130 LSSLSAQFKQ 140 NPKEVFSDFK 150 DLIGQILMEV 160 LMMSTQTRDE 170 NPFASLTATS 180 QPIAAAARSP 190 DRNLLLNAGS 200 NPGTSPMFCS 210 AGSFGASSLS 220 SLGASGGAST 230 WDSYSDHFTI 240 ETCKETDMLN 250 YLIECFDRVG 260 IEEKKAPKMC 270 SQPAVSQLLS 280 NIRSQCISHT 290 ALVLQGSLTQ 300 PRSMQQPSFL 310 VPYMLCRNLP 320 YGFIQELVRT 330 THQDEEVFKQ 340 IFIPILQGLA 350 LAAKECSLDS 360 DYFKYPLMAL 370 GELCETKFGK 380 THPVCNLVAS 390 LPLWLPKSLS 400 PGSGRELQRL 410 SYLGAFFSFS 420 VFAEDDAKVV 430 EKYFSGPAIT 440 LENTRVVSQS 450 LQHYLELGRQ 460 ELFKILHSIL 470 LNGETREAAL 480 GYMAAVVNAN 490 MKKAQMQTDD 500 RLVSTDGFML 510 NFLWVLQQLS 520 TKIKLETVDP 530 TYIFHPRCRI 540 TLPNDETRVN 550 ATMEDVNDWL 560 TELYGDQPPY 570 SEPKFPTECF 580 FLTLHAHHLS 590 ILPSCRRYIR 600 RLRAIRELNR 610 TVEDLKNNES 620 QWKDSPLATR 630 HREMLKRCKT 640 QLKKLVRCKA 650 CADAGLLDES 660 FLRRCLNFYG 670 LLIQLLLRIL 680 DPAYPDVTLP 690 LNSDVPKVFA 700 ALPEFYVEDV 710 AEFLFFIVQY 720 SPQVLYEPCT 730 QDIVMFLVVM 740 LCNQNYIRNP 750 YLVAKLVEVM 760 FMTNPAVQPR 770 TQKFFEMIEN 780 HPLSTKLLVP 790 SLMKFYTDVE 800 HTGATSEFYD 810 KFTIRYHIST 820 IFKSLWQNLA 830 HHGTFMDEFN 840 SGKQFVRYIN 850 MLINDTTFLL 860 DESLESLKRI 870 HEVQEEMKNK 880 EQWDQLPRDQ 890 QQARQSQLAQ 900 DERVSRSYLA 910 LATETVDMFH 920 ILTKQVQKPF 930 LRPELGPRLA 940 AMLNFNLQQL 950 CGPKCRDLKV 960 ENPEKYGFEP 970 KKLLDQLTDI 980 YLQLDCARFA 990 KAIADDQRSY 1000 SKELFEEVIS 1010 KMRKAGIKST 1020 IAIEKFKLLA 1030 EKVEEIVAKN 1040 ARAEIDYSDA 1050 PDEFRDPLMD 1060 TLMTDPVRLP 1070 SGTIMDRSII 1080 LRHLLNSPTD 1090 PFNRQTLTES 1100 MLEPVPELKE 1110 QIHAWMREKQ NSDH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000151	ubiquitin ligase complex
Molecular Function	GO:0034450	ubiquitin-ubiquitin ligase activity
Biological Process	GO:0036503	ERAD pathway
Biological Process	GO:0000209	protein polyubiquitination
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.