Search Results
Overview
| Uniprot ID | I3LQI9 |
|---|---|
| Protein Name | Rap1 GTPase-GDP dissociation stimulator 1 |
| Gene Name | RAP1GDS1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 315 | QKLFEGGKGNVFQRV |
| 396 | LAIPVVNKAKMLSAG |
| 590 | KLRGHENKSVAQQAS |
Function
Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA. Acts as a GEF for RHOC. Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases. Escorts RAC1 to the nucleus
Protein Sequence
10
MADNLSDTLK
20
KLKITAVDRT
30
DDSLEGCLDC
40
LLQALAQNNT
50
ETSEKIQGSG
60
ILHLFSSLLI
70
PQSSCTAKVA
80
NIIAELAKNE
90
FMRIPCVDAG
100
LISPLVQLLN
110
SKDQEVLLQT
120
GRALGNICYD
130
SHEGRSAVDQ
140
AGGAQIVVDH
150
LRSLCSITDP
160
ANEKLLTVFC
170
GMLMNYSNEN
180
DSLQAQLINM
190
GVIPTLVKLL
200
GIHCQNAALT
210
EMCLVAFGNL
220
AELESSKEQF
230
ASTNIAEELV
240
KLFKKQIEHD
250
KREMIFEVLA
260
PLAENDAIKL
270
QLVEAGLVEC
280
LLEIVQQKVD
290
SDKEEDIAEL
300
KTASDLMVLL
310
LLGDESMQKL
320
FEGGKGNVFQ
330
RVLSWIPSNN
340
HQLQLAGALA
350
IANFARNDGN
360
CIHMVDNGIV
370
EKLMDLLDRH
380
VEDGNVTVQH
390
AALSALRNLA
400
IPVVNKAKML
410
SAGVTEAVLK
420
FLKSEMPPVQ
430
FKLLGTLRML
440
IDAQEAAEQL
450
GKNVKLVERL
460
VEWCEAKDHA
470
GVMGESNRLL
480
SALIRHSKSK
490
DVIKTIVQSG
500
GIKHLVTMAT
510
SEHVIMQNEA
520
LVALALIAAL
530
ELGTAEKDLE
540
SAKLVQILHR
550
LLADERSAPE
560
IKYNSMVLIC
570
ALMGSESLHK
580
EVQDLAFLDV
590
VSKLRGHENK
600
SVAQQASLTE
QRLAVES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Biological Process | GO:0080120 | CAAX-box protein maturation |
| Biological Process | GO:0032471 | negative regulation of endoplasmic reticulum calcium ion concentration |
| Biological Process | GO:0051561 | positive regulation of mitochondrial calcium ion concentration |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0010821 | regulation of mitochondrion organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.