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Overview

Uniprot IDI3LQQ6
Protein NamePlasminogen activator inhibitor 1
Gene NameSERPINE1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
51 RQVVQASKDRNVVFS

Function

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis

Protein Sequence

10 MRMSLVFACL 20 AMGLALIFAE 30 GSASSHHQSL 40 AARLATDFGV 50 KVFRQVVQAS 60 KDRNVVFSPY 70 GVASVLAMLQ 80 LTTAGDTQQQ 90 IQEAMQFKIE 100 EKGMAPALRQ 110 LYKELMGPWN 120 KDEISTADAI 130 FVQRDLKLVQ 140 GFMPYFFRLF 150 RTTVKQVDFE 160 MDRARFIIND 170 WVKRHTKGMI 180 NDLLGQGAVD 190 QLTRLVLVNA 200 LYFNGQWKTP 210 FPEKSTHHRL 220 FHKSDGSTVS 230 VPMMAQTNKF 240 NYTEFSTPDG 250 HYYDILELPY 260 HGNTLSMFIA 270 APYEKEVPLS 280 ALTSILDAQL 290 ISQWKGNMTR 300 LTRLLVLPKF 310 SLESEVDLRR 320 PLENLGMTDM 330 FRPNQADFSS 340 LSDQELLYMS 350 QALQKVKIEV 360 NESGTVASSS 370 TAIIVSARMA 380 PEEIIMDRPF 390 LFVVRHNPTG 400 TVLFMGQVME P

Gene Ontology

Classification GO ID Description
Biological Process GO:0050820 positive regulation of coagulation
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005615 extracellular space
Molecular Function GO:0002020 protease binding
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0097187 dentinogenesis
Biological Process GO:0030195 negative regulation of blood coagulation
Biological Process GO:0033629 negative regulation of cell adhesion mediated by integrin
Biological Process GO:2000352 negative regulation of endothelial cell apoptotic process
Biological Process GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0051918 negative regulation of fibrinolysis
Biological Process GO:2001045 negative regulation of integrin-mediated signaling pathway
Biological Process GO:0010757 negative regulation of plasminogen activation
Biological Process GO:0014912 negative regulation of smooth muscle cell migration
Biological Process GO:2000098 negative regulation of smooth muscle cell-matrix adhesion
Biological Process GO:0070495 negative regulation of thrombin-activated receptor signaling pathway
Biological Process GO:0061044 negative regulation of vascular wound healing
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:0035491 positive regulation of leukotriene production involved in inflammatory response
Biological Process GO:0090026 positive regulation of monocyte chemotaxis
Biological Process GO:1901331 positive regulation of odontoblast differentiation
Biological Process GO:0048260 positive regulation of receptor-mediated endocytosis
Biological Process GO:0090399 replicative senescence

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.