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Overview

Uniprot ID	I3LR30
Protein Name	CAAX prenyl protease
Gene Name	ZMPSTE24
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
259	VYVVEGSKRSSHSNA

Function

Proteolytically removes the C-terminal three residues of farnesylated proteins

Protein Sequence

10 MGMWASLDAM 20 WEMPAEKRIF 30 GAVLLFSWTV 40 YLWETFLAQR 50 QRRIYKTTTH 60 VPLELGQIMD 70 SETFEKSRLY 80 QLDKSTFSFW 90 SGLYSEIEGT 100 LILLFGGIPY 110 LWRLSGRFCG 120 YAGFGPEYEI 130 TQSLVFLLLA 140 TLFSALTGLP 150 WSLYNTFVIE 160 EKHGFNQQTL 170 GFFMKDAIKK 180 FIVTQCILLP 190 VSSLLLYIIK 200 IGGDYFFIYA 210 WLFTLVVSLV 220 LVTIYADYIA 230 PLFDKFTPLP 240 EGKLKQEIEI 250 MAKSIDFPLT 260 KVYVVEGSKR 270 SSHSNAYFYG 280 FFKNKRIVLF 290 DTLLEEYSVL 300 NKDIQEESGM 310 EPRNDGEGDS 320 EEIKAKVKNK 330 KQGCKNEEVL 340 AVLGHELGHW 350 KLGHTVKNIV 360 ISQVNSFLCF 370 FLFAVLIGRK 380 ELFVAFGFYD 390 SQPTLIGLLI 400 IFQFIFSPYN 410 EVLSFCLTVL 420 SRRFEFQADA 430 FAKKLGKAKD 440 LYSALIKLNK 450 DNLGFPVSDW 460 LFSMWHYSHP 470 PLLERLQALK NSKQD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0071586	CAAX-box protein processing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.