Overview
| Uniprot ID | I3LR40 |
|---|
| Protein Name | Nucleoporin SEH1 |
|---|
| Gene Name | CEP192 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 288 |
DVRIFTLKPVRKELT |
Function
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex
Protein Sequence
10
MTGRGWGAAQ
20
PGARKQHAGS
30
TAARALAPGP
40
SGLRSAPMFV
50
ARSIAADHKD
60
LIHDVSFDFH
70
GRRMATCSSD
80
QSVKVWDKSE
90
SGDWHCTASW
100
KTHSGSVWRV
110
TWAHPEFGQV
120
LASCSFDRTA
130
AVWEEIVGES
140
NDKLRGQSHW
150
VKRTTLVDSR
160
TSVTDVKFAP
170
KHMGLMLATC
180
SADGIVRIYE
190
APDVMNLSQW
200
SLQHEVSCKL
210
SCSCISWNPS
220
SSRAHPPMIA
230
VGSDDGSPNA
240
MAKVQIFEYN
250
ENTRKYAKAE
260
TLMTVTDPVH
270
DIAFAPNLGR
280
SFHILAIATK
290
DVRIFTLKPV
300
RKELTSSGGP
310
TKFEIQVVAQ
320
FDNHNSQVWR
330
VSWNITGTVL
340
ASSGDDGCVR
350
LWKANYMDNW
360
KCTGILKGNG
370
SPVSGSSQQG
380
NANPSLGSNT
390
PNLQHSLNGS
400
SASRCFFPPL
410
DSPRAAWSRP
420
SYAQLPPPPP
430
LVEHSCAADT
440
ASLQYPHPRR
450
PSLSRPLNPL
PENEGV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0061700 |
GATOR2 complex |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0031080 |
nuclear pore outer ring |
| Cellular Component |
GO:0035859 |
Seh1-associated complex |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0051315 |
attachment of mitotic spindle microtubules to kinetochore |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0034198 |
cellular response to amino acid starvation |
| Biological Process |
GO:0006999 |
nuclear pore organization |
| Biological Process |
GO:1904263 |
positive regulation of TORC1 signaling |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0031503 |
protein-containing complex localization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.