Search Results
Overview
| Uniprot ID | I3LRC4 |
|---|---|
| Protein Name | Tyrosine--tRNA ligase |
| Gene Name | YARS2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 368 | QEGLDSAKRWCTQAL |
Function
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)
Protein Sequence
10
MAAPMLRRVS
20
RGRWLGTPGQ
30
SGVLPLGLRK
40
AHSGAQGLLA
50
VQKARGLFKE
60
FFPERGTKTE
70
LPELFDRGLA
80
GNVPQTIYCG
90
FDPTADSLHV
100
GHLLALLGLF
110
HFQRAGHNVI
120
ALVGGATARL
130
GDPSGRTKER
140
EALDAERVQS
150
NALALRQGLQ
160
ALAANHQQLF
170
TNGRSWGSFT
180
VLDNSAWYQK
190
QHLVDFLATV
200
GGHFRMGTLL
210
SRLSVQSRLK
220
SPEGMSLAEF
230
LYQVLQAYDF
240
YYLFQHYGCR
250
VQLGGADQLG
260
NIMSGYEFIH
270
KVTGEDVFGI
280
SVPLITSTTG
290
AKLGKSAGNA
300
VWLNREKTSP
310
FELYQFFVRL
320
QDNLVERYLK
330
LFTFLPLPEI
340
DHIMQLHVKE
350
PEKRGPQKRL
360
AAEVTKLVHG
370
QEGLDSAKRW
380
CTQALYHSSI
390
DALEVMSDQE
400
LKELFKEASF
410
SELVLDPGTS
420
VLDTCRKANA
430
IPDGPRGYRM
440
ITEGGVSINH
450
RQVTNPESVL
460
VVGQHILKNG
470
LSLLKIGKRN
FYIIKWLQL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0072545 | L-tyrosine binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Molecular Function | GO:0004831 | tyrosine-tRNA ligase activity |
| Biological Process | GO:0070184 | mitochondrial tyrosyl-tRNA aminoacylation |
| Biological Process | GO:0043039 | tRNA aminoacylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.