Search Results
Overview
| Uniprot ID | I3LS26 |
|---|---|
| Protein Name | Prosaposin |
| Gene Name | PSAP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 482 | TARVTPLKDGGFCEV |
| 565 | GACPSAHKPLLGTEK |
Function
Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling
Protein Sequence
10
MRSQPRPGLG
20
PCYWHLPAIG
30
GSASACPRPC
40
EHKGIPGSVT
50
DCGRHPLCHH
60
QERPRLITQK
70
PTLRQAFEYC
80
KFSEVKTSMY
90
TLFLLAGLLG
100
AALASPVLGL
110
RECTRGSAVW
120
CQNVKTASDC
130
GALQHCLQTV
140
WNKPTVKSLP
150
CDICKDVITA
160
AGDMLKDNAT
170
EQEILVYLER
180
TCDWLPKPNM
190
SATCKEIVDS
200
YFPVILDMIK
210
GQMSKPGEVC
220
SALNLCESLQ
230
KHLAELTQQK
240
QLESNQIPEL
250
DLAEAVAPFM
260
ANIPLLLYPQ
270
DGSSSKPRPK
280
ADGDVCQDCI
290
QMVTDLQNAV
300
RTNSTFVEAL
310
VNHAKEECDR
320
LGPGMADMCK
330
NYISQYSEIA
340
IQMMMHMQPK
350
DICGLVGFCE
360
EVKEVPMQTL
370
VPAKVLSEKV
380
ISALELVEPI
390
KKDLVPEKAT
400
IYCEVCEFVV
410
KEVAKLIDNN
420
RTEEEIIHAL
430
DKVCSKLPTS
440
MSEECQELVD
450
TYGSSILSLL
460
LQEASPELVC
470
SMLHLCSTQG
480
LPVLTARVTP
490
LKDGGFCEVC
500
KRLVSYLDRN
510
LEKNSTKQEI
520
LAALEKGCSF
530
LPDPYQKQCD
540
QFVTEYEPVL
550
VEILVEVMEP
560
SFVCSKIGAC
570
PSAHKPLLGT
580
EKCVWGPSFW
590
CQNMESAALC
600
NAVEHCKRHV
WN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:1905573 | ganglioside GM1 binding |
| Molecular Function | GO:1905574 | ganglioside GM2 binding |
| Molecular Function | GO:1905575 | ganglioside GM3 binding |
| Molecular Function | GO:1905577 | ganglioside GP1c binding |
| Molecular Function | GO:1905576 | ganglioside GT1b binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Biological Process | GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| Biological Process | GO:0060742 | epithelial cell differentiation involved in prostate gland development |
| Biological Process | GO:1905572 | ganglioside GM1 transport to membrane |
| Biological Process | GO:0007041 | lysosomal transport |
| Biological Process | GO:0060736 | prostate gland growth |
| Biological Process | GO:0019216 | regulation of lipid metabolic process |
| Biological Process | GO:0006665 | sphingolipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.