Overview
| Uniprot ID | I3LS70 |
|---|
| Protein Name | Importin subunit alpha |
|---|
| Gene Name | KPNA2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 108 |
RKLLSREKQPPIDNI |
Function
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1
Protein Sequence
10
MSTNENANSP
20
AARLNRFKNK
30
GKDSTEMRRR
40
RIEVNVELRK
50
AKKDDQMLKR
60
RNVSSFPDDA
70
TSPLQENRNN
80
QGTVNWSVDD
90
IVKGINSNNL
100
ESQLQATQAA
110
RKLLSREKQP
120
PIDNIIRAGL
130
IPKFVSFLGR
140
MDCSPIQFES
150
AWALTNIASG
160
TSEQTKAVVD
170
GGAIPAFISL
180
LASPHAHISE
190
QAVWALGNIA
200
GDGSVFRDLV
210
IKYGAVDPLL
220
ALLAVPDMSS
230
LACGYLRNLT
240
WTLSNLCRNK
250
NPAPPLDAVE
260
QILPTLVRLL
270
HHDDPEVLAD
280
TCWAISYLTD
290
GPNERIEMVV
300
KTGVVPQLVK
310
LLGATELPIV
320
TPALRAIGNI
330
VTGTDEQTQV
340
VIDAGALAVF
350
PSLLTNSKTN
360
IQKEATWTMS
370
NITAGRQDQI
380
QQVVNHGLVP
390
FLVGVLSKAD
400
FKTQKEAVWA
410
VTNYTSGGTV
420
EQIVYLVHCG
430
IIEPLMNLLT
440
AKDTKIILVI
450
LDAISNIFQA
460
AEKLGETEKL
470
SIMIEECGGL
480
DKIEALQNHE
490
NESVYKASLN
500
LIEKYFSVEE
510
EEDQNVVPET
520
TSEGYTFQVQ
DSATGTFNF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0043657 |
host cell |
| Cellular Component |
GO:0042564 |
NLS-dependent protein nuclear import complex |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0042826 |
histone deacetylase binding |
| Molecular Function |
GO:0061608 |
nuclear import signal receptor activity |
| Molecular Function |
GO:0008139 |
nuclear localization sequence binding |
| Biological Process |
GO:0075506 |
entry of viral genome into host nucleus through nuclear pore complex via importin |
| Biological Process |
GO:0006607 |
NLS-bearing protein import into nucleus |
| Biological Process |
GO:0032481 |
positive regulation of type I interferon production |
| Biological Process |
GO:1903902 |
positive regulation of viral life cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.