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Overview

Uniprot IDI3LT15
Protein NameAP2-associated protein kinase 1
Gene NameBMP2K
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
955 GKPRSLQKLTSRQRR

Function

Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity

Protein Sequence

10 MKKFSRMPKS 20 EGGGGGGGAA 30 GGGAGGAGAA 40 FGSGSGSSSV 50 GVRVFAVGRY 60 QVTLEESLAE 70 GGFSTVFLVR 80 THGGLRHALK 90 RMYVNNVTDL 100 NICKREITIM 110 KELSGHKNIV 120 GYLDCAVNSI 130 SDNVWEVLIL 140 MEYCRAGQVV 150 NQMNKKLQTG 160 FTEPEVLRIF 170 CDTCEAVARL 180 HQCKTPIIHR 190 DLKVENILLN 200 DCGNYVLCDF 210 GSATNKFLNP 220 QKDGVNIVEE 230 EIKKYTTLSY 240 RAPEMVNLYG 250 GKPITTKADI 260 WALGCLLYKL 270 CFFTLPFGES 280 QVAICDGSFT 290 IPDNSRYSHD 300 IHCLIRFMLE 310 PDPDRRPDIF 320 QVAHFAFKFA 330 KKDCPVSNIN 340 NSSIPSALPE 350 PMTASEAASR 360 KSQIKARITD 370 TIGPTETSIA 380 PRQRPKANST 390 TATPSVLTIQ 400 SSATPVKVPA 410 PGEFGNHRPK 420 GALRPGNSPE 430 SLLGQGPTQQ 440 PPQQHRVLQQ 450 LQQGDWRLQQ 460 LHLQHRHPHQ 470 QQQQQQQLLQ 480 DAYMQQYQHA 490 VQQQQILQQQ 500 FLMHSVYQPQ 510 ASASPYPAMM 520 QQYQQAFLQQ 530 QMLAQRQQSP 540 QQASPEYLTS 550 PQEFSPALVS 560 YTSSLPAQVG 570 TVMDSSHCAN 580 RSVADKEAVA 590 ADITNQKNIS 600 NPPDMSGWNP 610 FGEDNFSKLT 620 EEELLDREFD 630 LLRSNRLEER 640 ASSDESVEPH 650 SAPHPHPPGD 660 PFGSVPFISH 670 SGSPEKKIEP 680 ASTNQGNSTA 690 NPVKHRKASP 700 LSKDPRTGKK 710 PPETSSLPGQ 720 GPKGAEESES 730 DFESDPPSPK 740 SSEEEEEQDE 750 EPEEEGGLQG 760 EPGDFNDDDT 770 EPENLGHRPL 780 LMDSEDEEEE 790 EKHSSDSDDE 800 PAKAAASAAS 810 PGRRAAAGSG 820 PGRDPGAPRL 830 APARPPSAAG 840 PAAAQPEVDV 850 FGAVPFFSAR 860 APQPRQGERA 870 QAPCPRGQPG 880 PAAPVEPEEF 890 DVFTKAPFGR 900 KGTGPEAHGL 910 RAGAASVDVF 920 GSTPFQPFAA 930 AASRSGSSED 940 LFGLVPFEEI 950 AGSQQPRGKP 960 RSLQKLTSRQ 970 RRPKQDAAKS 980 NGKRHHGPAG 990 GAKKPAKPAY 1000 RTPERARRHR 1010 RAGRRDSQSS 1020 SEFLTVSDSK 1030 ENISVALPDG 1040 LPAEDSLLDP 1050 FGAKPFHPAD 1060 LPWHPPHQGL 1070 GDSNPVLPGR 1080 PRPGSLHGAF 1090 HGAEALKMDD 1100 FGAVPFTELV 1110 VQGLGSQQPQ 1120 QPQPGDLDPF GAAPFPSKQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005634 nucleus
Cellular Component GO:0098793 presynapse
Molecular Function GO:0035612 AP-2 adaptor complex binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0019208 phosphatase regulator activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Biological Process GO:0006897 endocytosis
Biological Process GO:0045747 positive regulation of Notch signaling pathway
Biological Process GO:0030500 regulation of bone mineralization
Biological Process GO:2000369 regulation of clathrin-dependent endocytosis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.