Search Results
Overview
| Uniprot ID | I3LTH4 |
|---|---|
| Protein Name | Cytosolic Fe-S cluster assembly factor NUBP1 |
| Gene Name | NUBP1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 218 | KEISFCHKVKLPIIG |
| 63 | KILVLSGKGGVGKST |
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure
Protein Sequence
10
MEEVPHDCPG
20
TGSAQAGRGA
30
SCQGCPNQRL
40
CASGAGAAPD
50
PAIEEIKEKM
60
KTVKHKILVL
70
SGKGGVGKST
80
FSAHLAHGLA
90
EDENTQVALL
100
DIDICGPSIP
110
KIMGLEGEQV
120
HQSGSGWSPV
130
FLEDNLGVMS
140
VGFLLSSPDD
150
AVIWRGPKKN
160
GMIKQFLRDV
170
DWGELDYLIV
180
DTPPGTSDEH
190
LSAVQYLAGA
200
HIDGAVLITT
210
PQEVSLQDVR
220
KEISFCHKVK
230
LPIIGVVENM
240
SSFLCPRCQK
250
ESQIFPPTTG
260
GAEVMCQDLK
270
IPLLGKVPLD
280
PRIGGCSAAA
290
ARGSPPPPLR
300
GAEEQGPPGG
310
GRPGRAEKRR
320
LGAPGTGRAL
330
RGPPRSGASM
RGAPSSQD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0140663 | ATP-dependent FeS chaperone activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0016226 | iron-sulfur cluster assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.