Search Results

Overview

Uniprot IDI3LUG7
Protein NameDNA mismatch repair protein
Gene NameMSH6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1293 TFLYKFIKGACPKSY
1317 LPEEVIQKGHRKARE
772 TCHTPFGKRLLKQWL

Function

Component of the post-replicative DNA mismatch repair system (MMR)

Protein Sequence

10 MSRQSTLYSF 20 FPKSPALTNA 30 NKAPARVSSE 40 GSAPAAAAGA 50 SPSPGGDAAW 60 SETGPGSGSP 70 AGSASRAEAR 80 KLNGGLRRSA 90 APAVPASSCD 100 FSPGDLVWAK 110 MEGYPWWPCL 120 VYNHPFDGTF 130 IREKGKSARV 140 HVQFFDDSPT 150 RGWVSRRLLK 160 PYTGSKSKEA 170 QKGGHFYSAK 180 PEILRAMQRA 190 DEALNKDKIK 200 RLELAVCDEP 210 SEPEEEEEME 220 AGAPYASEKS 230 EEENEMESEE 240 EVQPKVQGSR 250 RSSRHIKKRR 260 VISDSESDVG 270 GSDVEFKPDT 280 KEEGSSDEMS 290 SGVGDSDSEG 300 LDSPVKIAPK 310 RKRMVTGNGS 320 LKRKSSRKEM 330 PSATKRAIGI 340 SSETRSTLSA 350 FSAPQNSEPQ 360 AHISGGCDDS 370 NRPTVWYHET 380 LEWLKEERRR 390 DVHRRRPDHP 400 DFDASTLYVP 410 EDFLNSCTPG 420 MRKWWQIKSQ 430 NFDLVIFYKV 440 GKFYELYHMD 450 ALIGVSELGL 460 VFMKGNWAHS 470 GFPEIAFGRY 480 SDSLVQKGYK 490 VARVEQTETP 500 EMMEARCRKM 510 AHISKYDRVV 520 RREICRVITK 530 GTQTYSVLEG 540 DPSENYSKYL 550 LSLKEKEDDS 560 SGHTRVYGVC 570 FVDTSLGKFF 580 IGQFSDDRHC 590 SRFRTLVAHY 600 PPVQVLFEKG 610 SLSTETKMIL 620 KGSLSSSLQE 630 GLIPGSQFWD 640 AGKTLRTLLE 650 EGYFTDKLNE 660 DSGVMLPQVL 670 KGMTSESDSI 680 GLTPGEKSEL 690 ALSALGGCVF 700 YLKKCLIDQE 710 LLSMANFEEY 720 IPLDSDVVSA 730 SRPGAVFAKA 740 NQRMVLDAVT 750 LNNLEIFLNA 760 TNGSPEGTLL 770 EKIDTCHTPF 780 GKRLLKQWLC 790 APLCNPYAIS 800 DRLDAIEDLM 810 VVPDKISEVV 820 DLLKKLPDLE 830 RLLSKIHNVG 840 SPLKSQNHPD 850 SRAIMYEETT 860 YSKKKIIDFL 870 SALEGFKVIC 880 KIRGIMEEVI 890 DDFKSKILKQ 900 VLTLQTKNPE 910 GRFPDLTVEL 920 NRWDTAFDHE 930 KARKTGLITP 940 KAGFDSDYDQ 950 ALADIRENEQ 960 SLLEYLEKQR 970 SRIGCRTIVY 980 WGIGRNRYQL 990 EIPENFTTRN 1000 LPEEYELKST 1010 KKGCKRYWTK 1020 TIEKKLANLI 1030 NAEERRDVSL 1040 KDCMRRLFYN 1050 FDKNYKDWQA 1060 AVECIAVLDV 1070 LLCLANYSRG 1080 GDGPMCRPVI 1090 LLPGEDTPPF 1100 LYLKGSRHPC 1110 ITKTFFGDDF 1120 IPNDILIGCE 1130 EEEEENDKAY 1140 CVLVTGPNMG 1150 GKSTLMRQAG 1160 LLAVMAQMGC 1170 YVPAEVCRLT 1180 PIDRVFTRLG 1190 ASDRIMSGES 1200 TFFVELSETA 1210 SILTHATAHS 1220 LVLVDELGRG 1230 TATFDGTAIA 1240 NAVVKELAEN 1250 IKCRTLFSTH 1260 YHSLVEDYSQ 1270 NVAVRLGHMA 1280 CMVENECEDP 1290 SQETITFLYK 1300 FIKGACPKSY 1310 GFNAARLANL 1320 PEEVIQKGHR 1330 KAREFEKMTQ 1340 SLRLFREVCL 1350 ASERSTVDAE 1360 AVHKLLTLME EL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0032301 MutSalpha complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0140664 ATP-dependent DNA damage sensor activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0000400 four-way junction DNA binding
Molecular Function GO:0032137 guanine/thymine mispair binding
Molecular Function GO:0140003 histone H3K36me3 reader activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0030983 mismatched DNA binding
Molecular Function GO:0032405 MutLalpha complex binding
Molecular Function GO:0032357 oxidized purine DNA binding
Molecular Function GO:0032142 single guanine insertion binding
Molecular Function GO:0032143 single thymine insertion binding
Biological Process GO:0006298 mismatch repair
Biological Process GO:0045910 negative regulation of DNA recombination

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.