Search Results
Overview
| Uniprot ID | I3LUP1 |
|---|---|
| Protein Name | Mannose-1-phosphate guanylyltransferase regulatory subunit alpha |
| Gene Name | GMPPA |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | ILIGGPQKGTRFRPL |
Function
Regulatory subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex; reduces the catalytic activity of GMPPB when part of the complex. Mediates allosteric feedback inhibition of GMPPB catalytic activity upon binding GDP-alpha-D-mannose. Together with GMPPB regulates GDP-alpha-D-mannose levels
Protein Sequence
10
MLKAVILIGG
20
PQKGTRFRPL
30
SFEVPKPLFP
40
VAGVPMIQHH
50
IEACAQVPGM
60
QEILLIGFYQ
70
PDEPLTRFLE
80
AAQQEFNLPI
90
RYLQEFAPLG
100
TGGGLYHFRD
110
QILAGGPEAF
120
FVLNADVCSD
130
FPLSAMLDAH
140
RHRPHPFLLL
150
GTTANRTQSL
160
NYGCIVENPQ
170
THEVLHYVEK
180
PSTFVSDIIN
190
CGIYLFSPET
200
LKPLGKFFQR
210
YQQGGQLEDS
220
SVLWPGAGTI
230
RLEQDVFAAL
240
AGQGQIYVHL
250
TDGIWSQIKS
260
AGSALYASRL
270
YLSQYQLTHP
280
ERLAKHTPGG
290
PRIRGNVYIH
300
PTAKVAPSAV
310
LGPNVSIGEG
320
VTVGEGVRLR
330
ESIVLHGATL
340
QEHTCVLHSI
350
VGWGSTVGRW
360
ARVEGTPNDP
370
NPNDPRAHMD
380
SESLFKDGKL
390
LPAITILGCR
400
VRIPAEVLIL
410
NSIVLPHKEL
420
SRSFTNQIIL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0120508 | GDP-mannose pyrophosphorylase complex |
| Molecular Function | GO:0016740 | transferase activity |
| Biological Process | GO:0019673 | GDP-mannose metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.