Overview
| Uniprot ID | I3LVP8 |
|---|
| Protein Name | Katanin p60 ATPase-containing subunit A1 |
|---|
| Gene Name | KATNA1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 46 |
NKYLYSVKDTYLQQK |
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth
Protein Sequence
10
MSMSLLMISE
20
NVKLAREYAL
30
LGNYDSAMVY
40
YQGVLDQMNK
50
YLYSVKDTYL
60
QQKWQQVWQE
70
INVEAKHVKD
80
IMKTLESFKL
90
DSTPLKAAQH
100
ELPASEGEVW
110
SLPVPVERRP
120
SPGPRKRQSP
130
QYSDAKAHGN
140
RPSTAVRGHR
150
PSTHSLHNDR
160
GKTVRCREKK
170
EQNKGREEKN
180
KSPAAVTEPE
190
TNKFDSTGYD
200
KDLVEALERD
210
IISQNPNVRW
220
DDIADLVEAK
230
KLLKEAVVLP
240
MWMPEFFKGI
250
RRPWKGVLMV
260
GPPGTGKTLL
270
AKAVATECKT
280
TFFNVSSSTL
290
TSKYRGESEK
300
LVRLLFEMAR
310
FYSPATIFID
320
EIDSICSRRG
330
TSEEHEASRR
340
VKAELLVQMD
350
GVGGASENDD
360
PSKMVMVLAA
370
TNFPWDIDEA
380
LRRRLEKRIY
390
IPLPSAKGRE
400
ELLRISLREL
410
ELADDVDLAS
420
IAENMEGYSG
430
ADITNVCRDA
440
SLMAMRRRIE
450
GLTPEEIRNL
460
SKEEMHMPTT
470
MEDFEMALKK
480
VSKSVSAADI
490
ERYEKWIYEF
GSC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0034451 |
centriolar satellite |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0097431 |
mitotic spindle pole |
| Cellular Component |
GO:0005819 |
spindle |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0008568 |
microtubule severing ATPase activity |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0031122 |
cytoplasmic microtubule organization |
| Biological Process |
GO:0051013 |
microtubule severing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.