Overview
| Uniprot ID | I6NC86 |
|---|
| Protein Name | Cytochrome c oxidase subunit 1 |
|---|
| Gene Name | - |
|---|
| Organism | Frankliniella occidentalis |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 499 |
NWSIEWNKSAPTKEH |
| 504 |
WNKSAPTKEHCFEEN |
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Protein Sequence
10
MYKNNFLMKW
20
MFSSNHKDIG
30
ILYSLFGFWS
40
GMFGLSLSML
50
IRLNLRTSFK
60
LFISNDQFYN
70
SVVTAHAFVM
80
IFFTVMPIMI
90
GGFGNWLVPL
100
MLGAPDMAFP
110
RLNNMSFWLL
120
PPSLTLLIMG
130
SSKDGAGTGW
140
TVYPPLSTFY
150
HSGPSVDLTI
160
FSLHLAGISS
170
ILGALNFITT
180
ILNLKIKKLT
190
TEKMTLFVWS
200
VILTAILLLL
210
SLPVLAGAIT
220
MLLTDRNLNT
230
SFFDPSGGGD
240
PVLYQHLFWF
250
FGHPEVYILI
260
LPGFGLISHI
270
ITQESNKKST
280
FGLMGMIYAM
290
MAIGFLGFIV
300
WAHHMFTIGM
310
DVDTRAYFTS
320
ATMIIAVPTG
330
IKIFSWLATF
340
SGAKINMKVS
350
TLWSMGFVFL
360
FTLGGLTGVM
370
LSNSSIDIVL
380
HDTYYVVAHF
390
HYVLSMGAIF
400
AIFAGTVHWY
410
PLFTGLTMKK
420
KLLKIHFFLM
430
FIGVNLTFFP
440
QHFMGLSGMP
450
RRYSDYPFMF
460
ESWNKISSFG
470
SIISLMATIL
480
FIFILWESMA
490
SQRIVVMLNK
500
NNWSIEWNKS
510
APTKEHCFEE
NPKIFNF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045277 |
respiratory chain complex IV |
| Molecular Function |
GO:0004129 |
cytochrome-c oxidase activity |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0015990 |
electron transport coupled proton transport |
| Biological Process |
GO:0006123 |
mitochondrial electron transport, cytochrome c to oxygen |
Reference
[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.