Search Results
Overview
| Uniprot ID | K7GLQ8 |
|---|---|
| Protein Name | Four and a half LIM domains protein 1 |
| Gene Name | FHL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 115 | TFMAKDNKILCNKCT |
| 120 | DNKILCNKCTTREDS |
| 135 | PKCKGCFKPIVAGDQ |
| 147 | GDQNVEYKGTVWHKD |
| 153 | YKGTVWHKDCFTCSN |
| 173 | GTGSFFPKGEDFYCV |
| 186 | CVTCHETKFAKHCVK |
| 189 | CHETKFAKHCVKCNK |
| 193 | KFAKHCVKCNKAITS |
| 254 | AKKCAGCKNPITGFG |
| 262 | NPITGFGKGSSVVAY |
| 282 | HDYCFHCKKCSVNLA |
| 283 | DYCFHCKKCSVNLAN |
| 291 | CSVNLANKRFVFHQE |
| 307 | VYCPDCAKKL***** |
| 51 | QGKKYVQKDGHHCCL |
| 59 | DGHHCCLKCFDKFCA |
| 74 | NTCVECRKPIGADSK |
| 81 | KPIGADSKEVHYKNR |
Function
May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems
Protein Sequence
10
ITFSAASLAL
20
ELIWMLSSPT
30
GPSSYKVGTM
40
AEKFDCHYCR
50
DPLQGKKYVQ
60
KDGHHCCLKC
70
FDKFCANTCV
80
ECRKPIGADS
90
KEVHYKNRYW
100
HDTCFRCSKC
110
LHPLANETFM
120
AKDNKILCNK
130
CTTREDSPKC
140
KGCFKPIVAG
150
DQNVEYKGTV
160
WHKDCFTCSN
170
CKQVIGTGSF
180
FPKGEDFYCV
190
TCHETKFAKH
200
CVKCNKAITS
210
GGITYQDQPW
220
HAECFVCVTC
230
SKKLAGQRFT
240
AVEDQYYCVD
250
CYKNFVAKKC
260
AGCKNPITGF
270
GKGSSVVAYE
280
GQSWHDYCFH
290
CKKCSVNLAN
300
KRFVFHQEQV
YCPDCAKKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0007517 | muscle organ development |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.