Overview
| Uniprot ID | K7GLS3 |
|---|
| Protein Name | Motile sperm domain-containing protein 2 |
|---|
| Gene Name | MOSPD2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 371 |
VRTTAPEKYRVKPSN |
Function
Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins. In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis. The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs. Promotes migration of primary monocytes and neutrophils, in response to various chemokines
Protein Sequence
10
MAEYQAQNKP
20
KLIADVRRRF
30
EAEYVADKSD
40
KYDPRDVERL
50
QQDDNWVESY
60
LCWRHNIVDE
70
TLKMLDESFQ
80
WRKEMSVNDL
90
TEASIPRWLL
100
EIGGIYLHGY
110
DKEGNKLFWI
120
RVKYHIKDHK
130
TILDKKKLIA
140
FWLERYAKRE
150
NGKPVTVMFD
160
LSETGINSID
170
MDFVRFIINC
180
FKVYYPKYLS
190
KMVIFDMPWI
200
MNAAFKIVKS
210
WLGPEAVSLL
220
KFTTKNDVQD
230
YVSVEYLPPH
240
MGGSDPFKYS
250
YPPLVDDDFQ
260
TPLCENGPIA
270
SEDEASSKED
280
LESDGKESLE
290
TVSNEEQAAF
300
LKKSNVTEPT
310
SKAEESEKVD
320
SKMRAFKKPL
330
SVFKGPLLHI
340
SPAEELYFGS
350
TESGEKKALI
360
VLTNVTKNIV
370
AFKVRTTAPE
380
KYRVKPSNSS
390
CDPGASIDIV
400
VSPHGGLTVS
410
AQDRFLIMAA
420
EMEQSSGTGQ
430
TELTQFWKEV
440
PRNKVMEHRL
450
RCHIVESSKP
460
TTLTLKDHAF
470
NMSDKTNEDL
480
FLQLNRLLES
490
NRKLEDQVQR
500
CVWFQQLLLS
510
LTVLSLAFVI
SFFYLLYS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0140284 |
endoplasmic reticulum-endosome membrane contact site |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0033149 |
FFAT motif binding |
| Biological Process |
GO:0006935 |
chemotaxis |
| Biological Process |
GO:0140042 |
lipid droplet formation |
| Biological Process |
GO:0090026 |
positive regulation of monocyte chemotaxis |
| Biological Process |
GO:0090023 |
positive regulation of neutrophil chemotaxis |
| Biological Process |
GO:0051260 |
protein homooligomerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.