Search Results

Overview

Uniprot IDK7GLT8
Protein NameATP synthase subunit beta
Gene NameATP5F1B
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
166 EGLVRGQKVLDSGAP
175 LDSGAPIKIPVGPET
243 APYAKGGKIGLFGGA
468 DVARGVQKILQDYKS
527 LGKLVPLKETIKGFQ
564 EAVAKADKLAEEHS*

Function

Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain

Protein Sequence

10 MLRVISSKMI 20 QRTCLLQSRP 30 RPQLRGVGGQ 40 TAAALSLYPG 50 SAMLGFVGRV 60 ASASASGALR 70 GLSPSAPLPQ 80 AQLLLRAAPA 90 ALQPARDYAT 100 QPSPSPKAGA 110 ATGRIVAVIG 120 AVVDVQFDEG 130 LPPILNALEV 140 QGRETRLVLE 150 VAQHLGESTV 160 RTIAMDGTEG 170 LVRGQKVLDS 180 GAPIKIPVGP 190 ETLGRIMNVI 200 GEPIDERGPI 210 KTKQFAAIHA 220 EAPEFMEMSV 230 EQEILVTGIK 240 VVDLLAPYAK 250 GGKIGLFGGA 260 GVGKTVLIME 270 LINNVAKAHG 280 GYSVFAGVGE 290 RTREGNDLYH 300 EMIESGVINL 310 KDATSKVALV 320 YGQMNEPPGA 330 RARVALTGLT 340 VAEYFRDQEG 350 QDVLLFIDNI 360 FRFTQAGSEV 370 SALLGRIPSA 380 VGYQPTLATD 390 MGTMQERITT 400 TKKGSITSVQ 410 AIYVPADDLT 420 DPAPATTFAH 430 LDATTVLSRA 440 IAELGIYPAV 450 DPLDSTSRIM 460 DPNIVGSEHY 470 DVARGVQKIL 480 QDYKSLQDII 490 AILGMDELSE 500 EDKLTVSRAR 510 KIQRFLSQPF 520 QVAEVFTGHL 530 GKLVPLKETI 540 KGFQQILAGE 550 YDHLPEQAFY 560 MVGPIEEAVA 570 KADKLAEEHS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.