Search Results
Overview
| Uniprot ID | K7GRS5 |
|---|---|
| Protein Name | Stress-activated protein kinase JNK |
| Gene Name | MAPK8 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 160 | KPSNIVVKSDCTLKI |
| 251 | PCPEFMKKLQPTVRT |
Function
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity
Protein Sequence
10
MSRSKRDSNF
20
YSVEIGDSTF
30
TVLKRYQNLK
40
PIGSGAQGIV
50
CAAFDAILER
60
NVAIKKLSRP
70
FQNQTHAKRA
80
YRELVLMKCV
90
NHKNIIGLLN
100
VFTPQKSLEE
110
FQDVYIVMEL
120
MDANLCQVIQ
130
MELDHERMSY
140
LLYQMLCGIK
150
HLHSAGIIHR
160
DLKPSNIVVK
170
SDCTLKILDF
180
GLARTAGTSF
190
MMTPYVVTRY
200
YRAPEVILGM
210
GYKENVDLWS
220
VGCIMGEMVC
230
HKILFPGRDY
240
IDQWNKVIEQ
250
LGTPCPEFMK
260
KLQPTVRTYV
270
ENRPKYAGYS
280
FEKLFPDVLF
290
PADSEHNKLK
300
ASQARDLLSK
310
MLVIDASKRI
320
SVDEALQHPY
330
INVWYDPSEA
340
EAPPPKIPDK
350
QLDEREHTIE
360
EWKELIYKEV
370
MDLEERTKNG
380
VIRGQPSPLG
390
AAVINGSQHP
400
SSSSSVNDVS
410
SMSTDPTLAS
420
DTDSSLEASA
GPLGCCR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0035033 | histone deacetylase regulator activity |
| Molecular Function | GO:0004705 | JUN kinase activity |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0120283 | protein serine/threonine kinase binding |
| Biological Process | GO:0034198 | cellular response to amino acid starvation |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0034614 | cellular response to reactive oxygen species |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1900227 | positive regulation of NLRP3 inflammasome complex assembly |
| Biological Process | GO:0051247 | positive regulation of protein metabolic process |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0048511 | rhythmic process |
| Biological Process | GO:0051403 | stress-activated MAPK cascade |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.