Search Results
Overview
| Uniprot ID | K7GSP8 |
|---|---|
| Protein Name | - |
| Gene Name | PAK1IP1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 323 | QEEEGQPKADRKKCS |
Function
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly
Protein Sequence
10
MEVVAGCYEQ
20
VLFGFAVHPE
30
PETSGSHERK
40
WTPVADFTHH
50
AHTASLSAVA
60
VNSRFVVTGS
70
KDETIHIYDM
80
KKKVDHGALV
90
HHNGTITCLK
100
FYGNRHLISG
110
AEDGLICVWD
120
AKKWECLKSI
130
KAHKTWNLVE
140
GRSAFIKNIK
150
QNAHIVEWSP
160
RGEKYVVVIL
170
NKIDIYRLDT
180
ASVSGTITNA
190
KRVSSVTFLS
200
ESVLAVAGDE
210
EVVRFFDCDS
220
LTCLSEFKAH
230
ENRVKDVFSF
240
ETPEHHVIVT
250
ASSDGFIKMW
260
KLEEDKKVSP
270
SLLCEVNTNA
280
RLTCLGVWLD
290
TVTDTKESMP
300
PAAAPPPVSK
310
EERSKSSNKE
320
SGDAAQEEEG
330
QPKADRKKCS
340
VSGDSSKPAQ
350
GSSLVSAKKR
360
KMVEMLEKKK
370
KKKKKIGTVS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Molecular Function | GO:0004860 | protein kinase inhibitor activity |
| Biological Process | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process | GO:0009968 | negative regulation of signal transduction |
| Biological Process | GO:1901796 | regulation of signal transduction by p53 class mediator |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.