Overview
| Uniprot ID | K7GSY7 |
|---|
| Protein Name | RNA-binding protein FUS |
|---|
| Gene Name | FUS |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 308 |
GIIKTNKKTGQPMIN |
| 326 |
DRETGKLKGEATVSF |
| 357 |
EFSGNPIKVSFATRR |
| 443 |
CNQCKAPKPDGPGGG |
Function
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis
Protein Sequence
10
MASNDYTQQA
20
TQSYGAYPTQ
30
PGQGYSQQSN
40
QPYGQQSYSG
50
YGQSADTSGY
60
GQSSYGSSYG
70
QTQNTGYGAQ
80
SAPQGYGSTG
90
GYGSGQGSQS
100
SYGQQSSYPG
110
YGQQPAPSST
120
SGSYGTSSQS
130
SGYGQPQSGG
140
YGQQSGYGGQ
150
QQSYGQQQSY
160
NPPQGYGQQN
170
QYNSSSGGGG
180
GGGGGSYGQD
190
QPSMSGGGGG
200
GYGNQDQSGG
210
YGGGQQDRGG
220
RGRGGGSGGG
230
GGYNRSSGGY
240
EPRGRGGGRG
250
GRGGMGGSDR
260
GGFNKFGGPR
270
DQGSRHDSAE
280
QDNSDNNTIF
290
VQGLGENVTI
300
ESVADYFKQI
310
GIIKTNKKTG
320
QPMINLYTDR
330
ETGKLKGEAT
340
VSFDDPPSAK
350
AAIDWFDGKE
360
FSGNPIKVSF
370
ATRRADFNRG
380
GGNGRGGRGR
390
GGPMGRGGYG
400
GGGSGGGGRG
410
GFPSGGGGGG
420
GQQRAGDWKC
430
PNPTCENMNF
440
SWRNECNQCK
450
APKPDGPGGG
460
PGGSHMGGSY
470
GDDRRGGRGG
480
YDRGGYRGRG
490
GDRGGFRGGR
500
GGGDRGGFGP
510
GKMDSRGEHR
QDRRERPY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0098982 |
GABA-ergic synapse |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0099524 |
postsynaptic cytosol |
| Cellular Component |
GO:0099523 |
presynaptic cytosol |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0140693 |
molecular condensate scaffold activity |
| Molecular Function |
GO:0003730 |
mRNA 3'-UTR binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Molecular Function |
GO:0003712 |
transcription coregulator activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:1990000 |
amyloid fibril formation |
| Biological Process |
GO:0140694 |
membraneless organelle assembly |
| Biological Process |
GO:1905168 |
positive regulation of double-strand break repair via homologous recombination |
| Biological Process |
GO:0051260 |
protein homooligomerization |
| Biological Process |
GO:0043484 |
regulation of RNA splicing |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.