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Overview

Uniprot IDK7GT68
Protein NameIntegrin alpha-6
Gene NameITGA6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
144 KRQHVNTKQESRDIF
641 SNLKLEYKFCTREGN
877 VESKGLDKVACQPQR

Function

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling

Protein Sequence

10 MAAAGRLWLL 20 YLSAGLLPRL 30 GAAFNLDTRE 40 DNVIEKTGDS 50 GSLFGFSLAM 60 HRQLEPEEKR 70 LVLVGAPRAV 80 ALPLQKANRT 90 GGLYSCDITS 100 RGPCTRIEFD 110 NDADPSSESK 120 EDQWMGVTVQ 130 SQGPGGKVVT 140 CAHRYEKRQH 150 VNTKQESRDI 160 FGRCYVLSQN 170 LRIEDYMDGG 180 DWSFCDGRLR 190 GHEKFGSCQQ 200 GVAATFTKDY 210 HYIVFGAPGT 220 YNWKGIVRVE 230 QKNNTFFDMN 240 IFEDGPYEVG 250 GETDNDESLV 260 PVPANSYLGF 270 SLDSGKGIVS 280 KDEITFVSGA 290 PRANHSGAVV 300 LLKRDLKSAH 310 LLPEHIFDGE 320 GLASSFGYDV 330 AVVDLNSDGW 340 QDIVIGAPQY 350 FDRSGEVGGA 360 VYVYMNQQGR 370 WKNVKPIRLN 380 GTKDSMFGVA 390 VKNIGDINQD 400 GYPDIAVGAP 410 YDGKGKVFIY 420 HGSANGINTK 430 PTQVLEGKSP 440 SFGYSIAGNM 450 DLDRNWYPDV 460 AVGSLSDSVT 470 IFRSRPVINI 480 QQTITVTPNR 490 IDLRQKTSCG 500 APSGICLKVK 510 ACFEYTTKPA 520 NDDPSITIVG 530 TLEAEKERRK 540 SGLSSRVQFR 550 NQGSEPKYTQ 560 ELTLHRQKQK 570 ACMEETLWLQ 580 ENIRDKLRPI 590 PITASVEIQE 600 PSTRRRVNSL 610 PEVLPILNSN 620 EPKSVHTDVH 630 FLKEGCGADN 640 ICNSNLKLEY 650 KFCTREGNQD 660 KFSYLPIQKG 670 VPELVLKDQK 680 DIALEITVTN 690 SPSDRNPTKD 700 GDDAHEAKLI 710 ATFPDTLTYS 720 AYRELRAFPE 730 KQLSCVANQN 740 GSQADCELGN 750 PFKRNSSVTF 760 YLILSTTEVT 770 FDTTDLDINL 780 KLETTSNQDN 790 LASITATAKV 800 VIELLLSVSG 810 VAKPSQVYFG 820 GTVVGEQAMK 830 SEDEVGSLIE 840 YEFRVINLGK 850 PLKNLGTATL 860 NIQWPKEISN 870 GKWLLYLVKV 880 ESKGLDKVAC 890 QPQREINSLQ 900 LKESHNSRRK 910 REIAERQRDD 920 GRKFSLFAER 930 KYQTLNCSVN 940 VNCVNIRCPL 950 QGLDSKASVV 960 LRSRLWNSTF 970 LEEYSKMNYL 980 DILVRASIDM 990 TAATENIKLP 1000 NAGTQVRVTV 1010 FPSKTAAQYS 1020 GVPWWIILVA 1030 ILAGILMLAL 1040 LVFLLWKCGF 1050 FKRNKKDHYD 1060 ATYHKAEIHA 1070 QPSDKERLTS DA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0008305 integrin complex
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0031589 cell-substrate adhesion
Biological Process GO:0007229 integrin-mediated signaling pathway

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.