Overview
| Uniprot ID | K7N6K2 |
|---|
| Protein Name | E3 ubiquitin-protein ligase TRIM34B |
|---|
| Gene Name | Trim34b |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 152 |
KALTRLRKEQEKVET |
| 156 |
RLRKEQEKVETLEAD |
| 165 |
ETLEADIKEDRLSWK |
Function
Functions as antiviral protein and contributes to the defense against retroviral infections (By similarity). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (By similarity). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (By similarity). Regulates intestinal inflammation by controlling the exocytosis of the major component of colonic mucus MUC2 from colonic goblet cells (PubMed:32094504)
Protein Sequence
10
MASTGPTNIQ
20
EKTTCPVCQE
30
LLTKALSLGC
40
GHLVCQACLI
50
SNKNAVINPR
60
GKSSCPVCGT
70
RFSLENLQAN
80
KHLANVVERL
90
GEVKLKPDIG
100
TKRDLCVHHG
110
EKLLLFCKED
120
KKVICWVCER
130
SQEHRGHHTF
140
LWEEAVRECQ
150
ENLQKALTRL
160
RKEQEKVETL
170
EADIKEDRLS
180
WKRQVQTERQ
190
RIQTGFNQLR
200
RILDKEEQRE
210
LKRLREEEQM
220
ILDSLAGAEA
230
ELAQQSQLVE
240
ELISDLELRR
250
EWSDTELLQD
260
MSGILKWSQI
270
WTLKKPKAVS
280
KKLSMVFQAP
290
DLSGMLQKFR
300
ELSAVRAYWD
310
NFTFNPENLN
320
LNLILSEDHR
330
QVTSVSIWPF
340
KCCNNGILGS
350
KCFSSGKHYW
360
EVDVSEKNAW
370
TLGVYTRKRT
380
LRFDVRQRKG
390
QPNGYHRYKP
400
QNGYWVIGLQ
410
HGSKYSIFED
420
SSNCDPTVLN
430
PFVATPLHRV
440
GIFLDCEEGT
450
VSFLNVTNHG
460
SLIYKFSQCC
470
FSQPAYPYFN
480
PWDCPAPMTL
CPLNS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0061630 |
ubiquitin protein ligase activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0051607 |
defense response to virus |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0016567 |
protein ubiquitination |
| Biological Process |
GO:0010468 |
regulation of gene expression |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.