Search Results

Overview

Uniprot IDK9IVF7
Protein NameXaa-Pro aminopeptidase 1
Gene NameXPNPEP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
196 VKENLVDKIWTDRPE
330 ASLSPREKVWVSDKA
347 AVSEAIPKDHRCCMP
589 VVLVVPVKTKYNFNN
641 TCRDVIGKELQKQGR
664 RETQPISKQH*****

Function

Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Contributes to the degradation of bradykinin

Protein Sequence

10 MAASRKAPRV 20 RANYQDFQLK 30 NLRIIEPNEV 40 TRSGYPGVGT 50 DGRMAPKVTS 60 ELLRQLRQAM 70 KNLEYVTEPI 80 QAYIIPSGDA 90 HQSEYIAPCD 100 CRRAFVSGFD 110 GSAGTAIITE 120 EHAAMWTDGR 130 YFLQAAKQMD 140 SNWTLMKMGL 150 KDTPTQEDWL 160 VSVLPEGSRV 170 GVDPLIIPTD 180 YWKKMAKVLR 190 SAGHHLVPVK 200 ENLVDKIWTD 210 RPERPCKPLL 220 TLGLDYTGIS 230 WKDKVADLRL 240 KMAERNVVWF 250 VVTALDEIAW 260 LFNLRGSDVE 270 HNPVFFSYAI 280 IGLETIMLFI 290 DGDRIDTPSV 300 KEHLLFDLGL 310 EAEYRIQVLP 320 YKSILSELKV 330 LCASLSPREK 340 VWVSDKASYA 350 VSEAIPKDHR 360 CCMPYTPICI 370 AKAVKNSAES 380 EGMRRAHIKD 390 AVALCELFNW 400 LEKEVPKGGV 410 TEISAADKAE 420 EFRRQQADFV 430 DLSFPTISST 440 GPNGAIIHYA 450 PVPETNRTLS 460 LDEVYLIDSG 470 AQYKDGTTDV 480 TRTMHFGTPT 490 AYEKECFTYV 500 LKGHIAVSAA 510 VFPTGTKGHL 520 LDSFARSALW 530 DSGLDYLHGT 540 GHGVGSFLNV 550 HEGPCGISYK 560 TFSDEPLEAG 570 MIVTDEPGYY 580 EDGAFGIRIE 590 NVVLVVPVKT 600 KYNFNNRGSL 610 TFEPLTLVPI 620 QTKMIDVDSL 630 TDKECDWLNN 640 YHLTCRDVIG 650 KELQKQGRQE 660 ALEWLIRETQ PISKQH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0070006 metalloaminopeptidase activity
Biological Process GO:0006508 proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.