Overview
| Uniprot ID | M0R4H5 |
|---|
| Protein Name | PDZ and LIM domain protein 4 |
|---|
| Gene Name | Pdlim4 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 241 |
SGGSRNLKPAASKLG |
Function
Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons
Protein Sequence
10
MTHSVTLRGP
20
SPWGFRLVGG
30
RDFSAPLTIS
40
RVHAGSKAAL
50
AALCPGDLIQ
60
AINGESTELM
70
THLEAQNRIK
80
GCHDHLTLSV
90
SRPENKNWPS
100
SPDDKAQAHR
110
IHIDPEAQAS
120
LLQDGSPATS
130
RRSSISGISL
140
EDNRSGLGSP
150
YGQPPRLPVP
160
HNGSSNEVTL
170
PSQMSALHVS
180
PPPSADTPRI
190
LPRNRDCRVD
200
LGSEVYRMLR
210
EPAEPAASEP
220
KQSGSFRYLQ
230
GMLEAGEGGD
240
RPGSGGSRNL
250
KPAASKLGAP
260
LSGLQGLPEC
270
TRCGHGIVGT
280
IVKARDKLYH
290
PECFMCSDCG
300
LNLKQRGYFF
310
LDERLYCENH
320
AKARVKPPEG
330
YDVVAVYPNA
KVELV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0031941 |
filamentous actin |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Cellular Component |
GO:0001725 |
stress fiber |
| Molecular Function |
GO:0051393 |
alpha-actinin binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0019903 |
protein phosphatase binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.