Search Results
Overview
| Uniprot ID | M0R7F3 |
|---|---|
| Protein Name | Wiskott-Aldrich syndrome protein family member |
| Gene Name | Wasf3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | INMKKAFKSSTIQDQ |
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex
Protein Sequence
10
MPLVKRNIEP
20
RHLCRGALPE
30
GITSELECVT
40
NSTLAAIIRQ
50
LSSLSKHAED
60
IFGELFNEAN
70
NFYIRANSLQ
80
DRIDRLAVKV
90
TQLDSTVEEV
100
SLQDINMKKA
110
FKSSTIQDQQ
120
VVSKNSIPNP
130
VADIYNQSDK
140
PPPLSILTPY
150
RDDKKDGLKF
160
YTDPSYFFDL
170
WKEKMLQDTE
180
DKRKEKRRQK
190
EQKRVDGTTR
200
EVKKVRKARN
210
RRQEWNMMAY
220
DKELRPDNRL
230
SQSVHHGASS
240
EGSLSPDTRS
250
HTSDVTDYSY
260
PATPNHALQV
270
QPVTPSYTAG
280
DAPLHAATNQ
290
GAEHEYRPSS
300
ASARHMALNR
310
PQQPPPPPPP
320
QAPDGSQAST
330
SVAPADYGML
340
PAQIIEYYNP
350
SGPPPPPPPP
360
MIPSAQTAFV
370
SPLQIPAQQP
380
SFPASTGSTY
390
PTPPHQPSTG
400
LLATAPPPPG
410
PPPPPPGPPG
420
PSSLSSSPMH
430
GPPVAEAKRP
440
EPAQPPISDA
450
RSDLLAAIRM
460
GIQLKKVQEQ
470
REQEAKREPV
480
GNDVATILSR
490
RIAVEYSDSD
500
DDSEFDENDW
SD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0031209 | SCAR complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0071933 | Arp2/3 complex binding |
| Molecular Function | GO:0034237 | protein kinase A regulatory subunit binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0030032 | lamellipodium assembly |
| Biological Process | GO:0098885 | modification of postsynaptic actin cytoskeleton |
| Biological Process | GO:0014003 | oligodendrocyte development |
| Biological Process | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:0031643 | positive regulation of myelination |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.