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Overview

Uniprot IDM0R9N8
Protein NameAnillin
Gene NameAnlnl1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
722 EGPQRRNKTAVASQS

Function

Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration

Protein Sequence

10 MQIDPILLPG 20 VKLKSKWIKD 30 HHIKPDTLKL 40 IEEKVGKSLK 50 HMGTGENFLN 60 KTPMAYALRS 70 KLDKWDLKKL 80 QSFCKAKDTV 90 IRTKWQQRRH 100 WDSEITDDVS 110 ESSHFSPMPS 120 EEKPASPSKP 130 PVSNASATPV 140 GRRGRLANLA 150 ATICSWEDDV 160 SYSSAKQNSV 170 QEQPGTACLS 180 KSSSASGPSA 190 SINSSSVQQE 200 ATCCSQRDGN 210 ASVKKDPTSN 220 AADGPLLKAS 230 VSSPVKASSS 240 PVRSAPFITR 250 NCEVQSPELL 260 HKTVSPLKTE 270 VLKPCEKPTL 280 SQALQPKEGA 290 NKEVCLQSQS 300 KDKLATPGGR 310 GIKPFLERFG 320 ERCQEHSKES 330 PTCRAFHRTP 340 NITPNTKAIQ 350 ERLFKQNTCS 360 STTHLAQQLK 370 QEREKELACL 380 RGRFDKGSLW 390 SAEKDEKSRS 400 KQLETKQEVH 410 CQNSPLKKHQ 420 IVSGTPSTSV 430 SDKVAETPTA 440 VKISGTEPAG 450 STESEMTKSS 460 PLKITLFLEE 470 EKSLKVASDP 480 EVEQKTEAVH 490 EVEMSVDDED 500 INSSKVINDI 510 FSDVLEEGEL 520 DVEKSQEEMD 530 QVGTESSEEQ 540 EDALNISSMS 550 LLAPLAQTVG 560 VVNLQNVISS 570 PELELRDSSL 580 SAPSPKPGKF 590 QRTRVPQAES 600 GDSLSSEDRD 610 LLYSIDAYRS 620 QRFKETERPS 630 IKQVIVRKED 640 VTSKLSEKNG 650 VFSGQVNIKQ 660 KMQELNNDIN 670 LQQTVIYQAS 680 QALNCCVDEE 690 HGKGSLEEAE 700 AERLLLIATE 710 KRALLIDELN 720 KLKSEGPQRR 730 NKTAVASQSG 740 FAPSKGSVTL 750 SEICLPLKAE 760 FVCSTAQKPE 770 SSNYYYLIML 780 KAGAEQMVAT 790 PLASTANSLS 800 GDALTFPTTF 810 TLNDVSNDFE 820 INVEVYSLVQ 830 KKDSSGPEKK 840 KKASKSKAIT 850 PKRLLTSITS 860 KSSLHASVMA 870 SPGGLSAVRT 880 SNFTLVGSHT 890 LSLSSVGDTK 900 FALDKVPFLS 910 PLEGHICLKI 920 SCQVTSTVEE 930 KGFLTIFEDV 940 SGFGAWHRRW 950 CVLSGNCISY 960 WTYPDDERRK 970 NPIGRINLAN 980 CISHQIEPAN 990 REFCARRNTL 1000 ELITVRPQRE 1010 DDRETLVSQC 1020 RDTLCVTKNW 1030 LSADTKEERD 1040 LWMQKLNQVI 1050 VDIRLWQPDA CYKPVRKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005826 actomyosin contractile ring
Cellular Component GO:0032059 bleb
Biological Process GO:0000915 actomyosin contractile ring assembly
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0031106 septin ring organization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.