Search Results

Overview

Uniprot IDM0R9X8
Protein NameCytoplasmic dynein 1 heavy chain 1
Gene NameDync1h1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1226 FNDIMRRKDSAIQQQ
1807 QPPLRRRKLEHLITE
2966 YQIKVHRKYTGEDFD
369 LRKIRNTKYPIQRAL
4406 KRTVENIKDPLFRFF

Function

Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression

Protein Sequence

10 MSETGGGEDG 20 SAGLEVSAVQ 30 NVADVSVLQK 40 HLRKLVPLLL 50 EDGGDAPAAL 60 EAALEEKSAL 70 EQMRKFLSDP 80 QVHTVLVERS 90 TLKEDVGDEG 100 EEEKEFISYN 110 INIDIHYGVK 120 SNSLAFIKRA 130 PVIDADKPVS 140 SQLRVLTLSE 150 DSPYETLHSF 160 ISNAVAPFFK 170 SYIRESGKAD 180 RDGDKMAPSV 190 EKKIAELEMG 200 LLHLQQNIEI 210 PEISLPIHPI 220 ITNVAKQCYE 230 RGEKPKVTDF 240 GDKVEDPTFL 250 NQLQSGVNRW 260 IREIQKVTKL 270 DRDPASGTAL 280 QEISFWLNLE 290 RALYRIQEKR 300 ESPEVLLTLD 310 ILKHGKRFHA 320 TVSFDTDTGL 330 KQALETVNDY 340 NPLMKDFPLN 350 DLLSATELDK 360 IRQALVAIFT 370 HLRKIRNTKY 380 PIQRALRLVE 390 AISRDLSSQL 400 LKVLGTRKLM 410 HVAYEEFEKV 420 MVACFEVFQT 430 WDDEYEKLQV 440 LLRDIVKRKR 450 EENLKMVWRI 460 NPAHRKLQAR 470 LDQMRKFRRQ 480 HEQLRAVIVR 490 VLRPQVTAVA 500 QQNQGEAPEP 510 QDMKVAEVLF 520 DAADANAIEE 530 VNLAYENVKE 540 VDGLDVSKEG 550 TEAWEAAMKR 560 YDERIDRVET 570 RITARLRDQL 580 GTAKNANEMF 590 RIFSRFNALF 600 VRPHIRGAIR 610 EYQTQLIQRV 620 KDDIESLHDK 630 FKVQYPQSQA 640 CKMSHVRDLP 650 PVSGSIIWAK 660 QIDRQLTAYM 670 KRVEDVLGKG 680 WENHVEGQKL 690 KQDGDSFRMK 700 LNTQEIFDDW 710 ARKVQQRNLG 720 VSGRIFTIES 730 ARVRGRSGNV 740 LKLKVNFLPE 750 IITLSKEVRN 760 LKWLGFRVPL 770 AIVNKAHQAN 780 QLYPFAISLI 790 ESVRTYERTC 800 EKVEERNTIS 810 LLVAGLKKEV 820 QALIAEGIAL 830 VWESYKLDPY 840 VQRLAETVFN 850 FQEKVDDLLI 860 IEEKIDLEVR 870 SLETCMYDHK 880 TFSEILNRVQ 890 KAVDDLNLHS 900 YSNLPIWVNK 910 LDMEIERILG 920 VRLQAGLRAW 930 TQVLLGQAED 940 KAEVDMDTDA 950 PQVSHKPGGE 960 PKIKNVVHEL 970 RITNQVIYLN 980 PPIEECRYKL 990 YQEMFAWKMI 1000 VLSLPRIQSQ 1010 RYQVGVHYEL 1020 TEEEKFYRNA 1030 LTRMPDGPVA 1040 LEESYSAVMG 1050 IVTEVEQYVK 1060 VWLQYQCLWD 1070 MQAENIYNRL 1080 GEDLSKWQAL 1090 LVQIRRARGT 1100 FDNAETKKEF 1110 GPVVIDYGKV 1120 QSKVNLKYDS 1130 WHKEVLSKFG 1140 QMLGSNMTEF 1150 HSQISKSRQE 1160 LEQHSVDTAS 1170 TSDAVTFITY 1180 VQSLKRKIKQ 1190 FEKQVELYRN 1200 GQRLLEKQRF 1210 QFPPSWLYID 1220 NIEGEWGAFN 1230 DIMRRKDSAI 1240 QQQVANLQMK 1250 IVQEDRAVES 1260 RTTDLLTDWE 1270 KTKPVTGNLR 1280 PEEALQALTI 1290 YEGKFGRLKD 1300 DREKCAKAKE 1310 ALELTDTGLL 1320 SGSEERVQVA 1330 LEELQDLKGV 1340 WSELSKVWEQ 1350 IDQMKEQPWV 1360 SVQPRKLRQN 1370 LDGLLNQLKN 1380 FPARLRQYAS 1390 YEFVQRLLKG 1400 YMKINMLVIE 1410 LKSEALKDRH 1420 WKQLMKRLHV 1430 NWVVSELTLG 1440 QIWDVDLQKN 1450 EAIVKDVLLV 1460 AQGEMALEEF 1470 LKQASIREVW 1480 NTYELDLVNY 1490 QNKCRLIRGW 1500 DDLFNKVKEH 1510 INSVSAMKLS 1520 PYYKVFEEDA 1530 LSWEDKLNRI 1540 MALFDVWIDV 1550 QRRWVYLEGI 1560 FTGSADIKHL 1570 LPVETQRFQS 1580 ISTEFLALMK 1590 KVSKSPLVMD 1600 VLNIQGVQRS 1610 LERLADLLGK 1620 IQKALGEYLE 1630 RERSSFPRFY 1640 FVGDEDLLEI 1650 IGNSKNVAKL 1660 QKHFKKMFAG 1670 VSSIILNEDS 1680 SVVLGISSRE 1690 GEEVMFKTPV 1700 SITEHPKINE 1710 WLTLVEKEMR 1720 VTLAKLLAES 1730 VTEVEIFGKA 1740 TSIDPNTYIT 1750 WIDKYQAQLV 1760 VLSAQIAWSE 1770 NVENALSNVG 1780 GGGDVGPLQS 1790 VLSNVEVTLN 1800 VLADSVLMEQ 1810 PPLRRRKLEH 1820 LITELVHQRD 1830 VTRSLIKSKI 1840 DNAKSFEWLS 1850 QMRFYFDPKQ 1860 TDVLQQLSIQ 1870 MANAKFNYGF 1880 EYLGVQDKLV 1890 QTPLTDRCYL 1900 TMTQALEARL 1910 GGSPFGPAGT 1920 GKTESVKALG 1930 HQLGRFVLVF 1940 NCDETFDFQA 1950 MGRIFVGLCQ 1960 VGAWGCFDEF 1970 NRLEERMLSA 1980 VSQQVQCIQE 1990 ALREHSNPNY 2000 DKTSAPITCE 2010 LLNKQVKVSP 2020 DMAIFITMNP 2030 GYAGRSNLPD 2040 NLKKLFRSLA 2050 MTKPDRQLIA 2060 QVMLYSQGFR 2070 TAEVLANKIV 2080 PFFKLCDEQL 2090 SSQSHYDFGL 2100 RALKSVLVSA 2110 GNVKRERIQK 2120 IKREKEERGE 2130 AVDEGEIAEN 2140 LPEQEILIQS 2150 VCETMVPKLV 2160 AEDIPLLFSL 2170 LSDVFPGVQY 2180 HRGEMTALRE 2190 ELKKVCQEMY 2200 LTYGDGEEVG 2210 GMWVEKVLQL 2220 YQITQINHGL 2230 MMVGPSGSGK 2240 SMAWRVLLKA 2250 LERLEGVEGV 2260 AHIIDPKAIS 2270 KDHLYGTLDP 2280 NTREWTDGLF 2290 THVLRKIIDN 2300 VRGELQKRQW 2310 IVFDGDVDPE 2320 WVENLNSVLD 2330 DNKLLTLPNG 2340 ERLSLPPNVR 2350 IMFEVQDLKY 2360 ATLATVSRCG 2370 MVWFSEDVLS 2380 TDMIFNNFLA 2390 RLRSIPLDEG 2400 EDEAQRRRKG 2410 KEDEGEEAAS 2420 PMLQIQRDAA 2430 TIMQPYFTSN 2440 GLVTKALEHA 2450 FKLEHIMDLT 2460 RLRCLGSLFS 2470 MLHQACRNVA 2480 QYNANHPDFP 2490 MQIEQLERYI 2500 QRYLVYAILW 2510 SLSGDSRLKM 2520 RAELGEYIRR 2530 ITTVPLPTAP 2540 NIPIIDYEVS 2550 ISGEWSPWQA 2560 KVPQIEVETH 2570 KVAAPDVVVP 2580 TLDTVRHEAL 2590 LYTWLAEHKP 2600 LVLCGPPGSG 2610 KTMTLFSALR 2620 ALPDMEVVGL 2630 NFSSATTPEL 2640 LLKTFDHYCE 2650 YRRTPNGVVL 2660 APVQLGKWLV 2670 LFCDEINLPD 2680 MDKYGTQRVI 2690 SFIRQMVEHG 2700 GFYRTSDQTW 2710 VKLERIQFVG 2720 ACNPPTDPGR 2730 KPLSHRFLRH 2740 VPVVYVDYPG 2750 PASLTQIYGT 2760 FNRAMLRLIP 2770 SLRTYAEPLT 2780 AAMVEFYTMS 2790 QERFTQDTQP 2800 HYIYSPREMT 2810 RWVRGIFEAL 2820 RPLETLPVEG 2830 LIRIWAHEAL 2840 RLFQDRLVED 2850 EERRWTDENI 2860 DMVALKHFPN 2870 IDKEKAMSRP 2880 ILYSNWLSKD 2890 YIPVDQEELR 2900 DYVKARLKVF 2910 YEEELDVPLV 2920 LFNEVLDHVL 2930 RIDRIFRQPQ 2940 GHLLLIGVSG 2950 AGKTTLSRFV 2960 AWMNGLSVYQ 2970 IKVHRKYTGE 2980 DFDEDLRTVL 2990 RRSGCKNEKI 3000 AFIMDESNVL 3010 DSGFLERMNT 3020 LLANGEVPGL 3030 FEGDEYATLM 3040 TQCKEGAQKE 3050 GLMLDSHEEL 3060 YKWFTSQVIR 3070 NLHVVFTMNP 3080 SSEGLKDRAA 3090 TSPALFNRCV 3100 LNWFGDWSTE 3110 ALYQVGKEFT 3120 SKMDLEKPNY 3130 IVPDYMPVVY 3140 DKLPQPPTHR 3150 EAIVNSCVFV 3160 HQTLHQANAR 3170 LAKRGGRTMA 3180 ITPRHYLDFI 3190 NHYANLFHEK 3200 RSELEEQQMH 3210 LNVGLRKIKE 3220 TVDQVEELRR 3230 DLRIKSQELE 3240 VKNAAANDKL 3250 KKMVKDQQEA 3260 EKKKVMSQEI 3270 QEQLHKQQEV 3280 IADKQMSVKE 3290 DLDKVEPAVI 3300 EAQNAVKSIK 3310 KQHLVEVRSM 3320 ANPPAAVKLA 3330 LESICLLLGE 3340 STTDWKQIRS 3350 IIMRENFIPT 3360 IVNFSAEEIS 3370 DAIREKMKKN 3380 YMSNPSYNYE 3390 IVNRASLACG 3400 PMVKWAIAQL 3410 NYADMLKRVE 3420 PLRNELQKLE 3430 DDAKDNQQKA 3440 NEVEQMIRDL 3450 EASIARYKEE 3460 YAVLISEAQA 3470 IKADLAAVEA 3480 KVNRSTALLK 3490 SLSAERERWE 3500 KTSETFKNQM 3510 STIAGDCLLS 3520 AAFIAYAGYF 3530 DQQMRQNLFT 3540 TWSHHLQQAN 3550 IQFRTDIART 3560 EYLSNADERL 3570 RWQASSLPAD 3580 DLCTENAIML 3590 KRFNRYPLII 3600 DPSGQATEFI 3610 MNEYKDRKIT 3620 RTSFLDDAFR 3630 KNLESALRFG 3640 NPLLVQDVES 3650 YDPVLNPVLN 3660 REVRRTGGRV 3670 LITLGDQDID 3680 LSPSFVIFLS 3690 TRDPTVEFPP 3700 DLCSRVTFVN 3710 FTVTRSSLQS 3720 QCLNEVLKAE 3730 RPDVDEKRSD 3740 LLKLQGEFQL 3750 RLRQLEKSLL 3760 QALNEVKGRI 3770 LDDDTIITTL 3780 ENLKREAAEV 3790 TRKVEETDIV 3800 MQEVETVSQQ 3810 YLPLSTACSS 3820 IYFTMESLKQ 3830 VHFLYQYSLQ 3840 FFLDIYHNVL 3850 YENPNLKGAT 3860 DHTQRLSVIT 3870 KDLFQVAFNR 3880 VARGMLHQDH 3890 ITFAMLLARI 3900 KLKGTMGEPT 3910 YDAEFQHFLR 3920 GKEIVLSAGS 3930 TPKVQGLTVE 3940 QAEAVARLSC 3950 LPAFKDLIAK 3960 VQADEQFGIW 3970 LESSSPEQTV 3980 PYLWTEETPA 3990 TPIGQAIHRL 4000 LLIQAFRPDR 4010 LLAMAHMFVS 4020 TNLGESFMSI 4030 MEQPLDLTHI 4040 VGTEVKPNTP 4050 VLMCSVPGYD 4060 ASGHVEDLAA 4070 EQNTQITSIA 4080 IGSAEGFNQA 4090 DKAINTAVKS 4100 GRWVMLKNVH 4110 LAPGWLMQLE 4120 KKLHSLQPHA 4130 CFRLFLTMEI 4140 NPKVPVNLLR 4150 AGRIFVFEPP 4160 PGVKANMLRT 4170 FSSIPVSRMC 4180 KSPNERARLY 4190 FLLAWFHAVI 4200 QERLRYAPLG 4210 WSKKYEFGES 4220 DLRSACDTVD 4230 TWLDDTAKGR 4240 QNISPDKIPW 4250 SALKTLMAQS 4260 IYGGRVDNEF 4270 DQRLLNTFLE 4280 RLFTTRSFDS 4290 EFKLACKVDG 4300 HKDIQMPDGI 4310 RREEFVQWVE 4320 LLPDAQTPSW 4330 LGLPNNAERV 4340 LLTTQGVDMI 4350 SKMLKMQMLE 4360 DEDDLAYAET 4370 EKKTRTDSTS 4380 DGRPAWMRTL 4390 HTTASNWLHL 4400 IPQTLSPLKR 4410 TVENIKDPLF 4420 RFFEREVKMG 4430 AKLLQDVRQD 4440 LADVVQVCEG 4450 KKKQTNYLRT 4460 LINELVKGIL 4470 PRSWSHYTVP 4480 AGMTVIQWVS 4490 DFSERIKQLQ 4500 NISQAAAAGG 4510 AKELKNIHVC 4520 LGGLFVPEAY 4530 ITATRQYVAQ 4540 ANSWSLEELC 4550 LEVNVTASQS 4560 TTLDACSFGV 4570 TGLKLQGATC 4580 SNNKLSLSNA 4590 ISTVLPLTQL 4600 RWGKQTSAEK 4610 KASVVTLPVY 4620 LNFTRADLIF 4630 TVDFEIATKE 4640 DPRSFYERGV AVLCTE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005868 cytoplasmic dynein complex
Cellular Component GO:0030175 filopodium
Cellular Component GO:0005874 microtubule
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0051959 dynein light intermediate chain binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008569 minus-end-directed microtubule motor activity
Biological Process GO:0051301 cell division
Biological Process GO:0051293 establishment of spindle localization
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0033962 P-body assembly
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0032388 positive regulation of intracellular transport
Biological Process GO:1905832 positive regulation of spindle assembly
Biological Process GO:0090235 regulation of metaphase plate congression
Biological Process GO:0060236 regulation of mitotic spindle organization
Biological Process GO:0034063 stress granule assembly

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.