Search Results
Overview
| Uniprot ID | M0R9X8 |
|---|---|
| Protein Name | Cytoplasmic dynein 1 heavy chain 1 |
| Gene Name | Dync1h1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1226 | FNDIMRRKDSAIQQQ |
| 1807 | QPPLRRRKLEHLITE |
| 2966 | YQIKVHRKYTGEDFD |
| 369 | LRKIRNTKYPIQRAL |
| 4406 | KRTVENIKDPLFRFF |
Function
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression
Protein Sequence
10
MSETGGGEDG
20
SAGLEVSAVQ
30
NVADVSVLQK
40
HLRKLVPLLL
50
EDGGDAPAAL
60
EAALEEKSAL
70
EQMRKFLSDP
80
QVHTVLVERS
90
TLKEDVGDEG
100
EEEKEFISYN
110
INIDIHYGVK
120
SNSLAFIKRA
130
PVIDADKPVS
140
SQLRVLTLSE
150
DSPYETLHSF
160
ISNAVAPFFK
170
SYIRESGKAD
180
RDGDKMAPSV
190
EKKIAELEMG
200
LLHLQQNIEI
210
PEISLPIHPI
220
ITNVAKQCYE
230
RGEKPKVTDF
240
GDKVEDPTFL
250
NQLQSGVNRW
260
IREIQKVTKL
270
DRDPASGTAL
280
QEISFWLNLE
290
RALYRIQEKR
300
ESPEVLLTLD
310
ILKHGKRFHA
320
TVSFDTDTGL
330
KQALETVNDY
340
NPLMKDFPLN
350
DLLSATELDK
360
IRQALVAIFT
370
HLRKIRNTKY
380
PIQRALRLVE
390
AISRDLSSQL
400
LKVLGTRKLM
410
HVAYEEFEKV
420
MVACFEVFQT
430
WDDEYEKLQV
440
LLRDIVKRKR
450
EENLKMVWRI
460
NPAHRKLQAR
470
LDQMRKFRRQ
480
HEQLRAVIVR
490
VLRPQVTAVA
500
QQNQGEAPEP
510
QDMKVAEVLF
520
DAADANAIEE
530
VNLAYENVKE
540
VDGLDVSKEG
550
TEAWEAAMKR
560
YDERIDRVET
570
RITARLRDQL
580
GTAKNANEMF
590
RIFSRFNALF
600
VRPHIRGAIR
610
EYQTQLIQRV
620
KDDIESLHDK
630
FKVQYPQSQA
640
CKMSHVRDLP
650
PVSGSIIWAK
660
QIDRQLTAYM
670
KRVEDVLGKG
680
WENHVEGQKL
690
KQDGDSFRMK
700
LNTQEIFDDW
710
ARKVQQRNLG
720
VSGRIFTIES
730
ARVRGRSGNV
740
LKLKVNFLPE
750
IITLSKEVRN
760
LKWLGFRVPL
770
AIVNKAHQAN
780
QLYPFAISLI
790
ESVRTYERTC
800
EKVEERNTIS
810
LLVAGLKKEV
820
QALIAEGIAL
830
VWESYKLDPY
840
VQRLAETVFN
850
FQEKVDDLLI
860
IEEKIDLEVR
870
SLETCMYDHK
880
TFSEILNRVQ
890
KAVDDLNLHS
900
YSNLPIWVNK
910
LDMEIERILG
920
VRLQAGLRAW
930
TQVLLGQAED
940
KAEVDMDTDA
950
PQVSHKPGGE
960
PKIKNVVHEL
970
RITNQVIYLN
980
PPIEECRYKL
990
YQEMFAWKMI
1000
VLSLPRIQSQ
1010
RYQVGVHYEL
1020
TEEEKFYRNA
1030
LTRMPDGPVA
1040
LEESYSAVMG
1050
IVTEVEQYVK
1060
VWLQYQCLWD
1070
MQAENIYNRL
1080
GEDLSKWQAL
1090
LVQIRRARGT
1100
FDNAETKKEF
1110
GPVVIDYGKV
1120
QSKVNLKYDS
1130
WHKEVLSKFG
1140
QMLGSNMTEF
1150
HSQISKSRQE
1160
LEQHSVDTAS
1170
TSDAVTFITY
1180
VQSLKRKIKQ
1190
FEKQVELYRN
1200
GQRLLEKQRF
1210
QFPPSWLYID
1220
NIEGEWGAFN
1230
DIMRRKDSAI
1240
QQQVANLQMK
1250
IVQEDRAVES
1260
RTTDLLTDWE
1270
KTKPVTGNLR
1280
PEEALQALTI
1290
YEGKFGRLKD
1300
DREKCAKAKE
1310
ALELTDTGLL
1320
SGSEERVQVA
1330
LEELQDLKGV
1340
WSELSKVWEQ
1350
IDQMKEQPWV
1360
SVQPRKLRQN
1370
LDGLLNQLKN
1380
FPARLRQYAS
1390
YEFVQRLLKG
1400
YMKINMLVIE
1410
LKSEALKDRH
1420
WKQLMKRLHV
1430
NWVVSELTLG
1440
QIWDVDLQKN
1450
EAIVKDVLLV
1460
AQGEMALEEF
1470
LKQASIREVW
1480
NTYELDLVNY
1490
QNKCRLIRGW
1500
DDLFNKVKEH
1510
INSVSAMKLS
1520
PYYKVFEEDA
1530
LSWEDKLNRI
1540
MALFDVWIDV
1550
QRRWVYLEGI
1560
FTGSADIKHL
1570
LPVETQRFQS
1580
ISTEFLALMK
1590
KVSKSPLVMD
1600
VLNIQGVQRS
1610
LERLADLLGK
1620
IQKALGEYLE
1630
RERSSFPRFY
1640
FVGDEDLLEI
1650
IGNSKNVAKL
1660
QKHFKKMFAG
1670
VSSIILNEDS
1680
SVVLGISSRE
1690
GEEVMFKTPV
1700
SITEHPKINE
1710
WLTLVEKEMR
1720
VTLAKLLAES
1730
VTEVEIFGKA
1740
TSIDPNTYIT
1750
WIDKYQAQLV
1760
VLSAQIAWSE
1770
NVENALSNVG
1780
GGGDVGPLQS
1790
VLSNVEVTLN
1800
VLADSVLMEQ
1810
PPLRRRKLEH
1820
LITELVHQRD
1830
VTRSLIKSKI
1840
DNAKSFEWLS
1850
QMRFYFDPKQ
1860
TDVLQQLSIQ
1870
MANAKFNYGF
1880
EYLGVQDKLV
1890
QTPLTDRCYL
1900
TMTQALEARL
1910
GGSPFGPAGT
1920
GKTESVKALG
1930
HQLGRFVLVF
1940
NCDETFDFQA
1950
MGRIFVGLCQ
1960
VGAWGCFDEF
1970
NRLEERMLSA
1980
VSQQVQCIQE
1990
ALREHSNPNY
2000
DKTSAPITCE
2010
LLNKQVKVSP
2020
DMAIFITMNP
2030
GYAGRSNLPD
2040
NLKKLFRSLA
2050
MTKPDRQLIA
2060
QVMLYSQGFR
2070
TAEVLANKIV
2080
PFFKLCDEQL
2090
SSQSHYDFGL
2100
RALKSVLVSA
2110
GNVKRERIQK
2120
IKREKEERGE
2130
AVDEGEIAEN
2140
LPEQEILIQS
2150
VCETMVPKLV
2160
AEDIPLLFSL
2170
LSDVFPGVQY
2180
HRGEMTALRE
2190
ELKKVCQEMY
2200
LTYGDGEEVG
2210
GMWVEKVLQL
2220
YQITQINHGL
2230
MMVGPSGSGK
2240
SMAWRVLLKA
2250
LERLEGVEGV
2260
AHIIDPKAIS
2270
KDHLYGTLDP
2280
NTREWTDGLF
2290
THVLRKIIDN
2300
VRGELQKRQW
2310
IVFDGDVDPE
2320
WVENLNSVLD
2330
DNKLLTLPNG
2340
ERLSLPPNVR
2350
IMFEVQDLKY
2360
ATLATVSRCG
2370
MVWFSEDVLS
2380
TDMIFNNFLA
2390
RLRSIPLDEG
2400
EDEAQRRRKG
2410
KEDEGEEAAS
2420
PMLQIQRDAA
2430
TIMQPYFTSN
2440
GLVTKALEHA
2450
FKLEHIMDLT
2460
RLRCLGSLFS
2470
MLHQACRNVA
2480
QYNANHPDFP
2490
MQIEQLERYI
2500
QRYLVYAILW
2510
SLSGDSRLKM
2520
RAELGEYIRR
2530
ITTVPLPTAP
2540
NIPIIDYEVS
2550
ISGEWSPWQA
2560
KVPQIEVETH
2570
KVAAPDVVVP
2580
TLDTVRHEAL
2590
LYTWLAEHKP
2600
LVLCGPPGSG
2610
KTMTLFSALR
2620
ALPDMEVVGL
2630
NFSSATTPEL
2640
LLKTFDHYCE
2650
YRRTPNGVVL
2660
APVQLGKWLV
2670
LFCDEINLPD
2680
MDKYGTQRVI
2690
SFIRQMVEHG
2700
GFYRTSDQTW
2710
VKLERIQFVG
2720
ACNPPTDPGR
2730
KPLSHRFLRH
2740
VPVVYVDYPG
2750
PASLTQIYGT
2760
FNRAMLRLIP
2770
SLRTYAEPLT
2780
AAMVEFYTMS
2790
QERFTQDTQP
2800
HYIYSPREMT
2810
RWVRGIFEAL
2820
RPLETLPVEG
2830
LIRIWAHEAL
2840
RLFQDRLVED
2850
EERRWTDENI
2860
DMVALKHFPN
2870
IDKEKAMSRP
2880
ILYSNWLSKD
2890
YIPVDQEELR
2900
DYVKARLKVF
2910
YEEELDVPLV
2920
LFNEVLDHVL
2930
RIDRIFRQPQ
2940
GHLLLIGVSG
2950
AGKTTLSRFV
2960
AWMNGLSVYQ
2970
IKVHRKYTGE
2980
DFDEDLRTVL
2990
RRSGCKNEKI
3000
AFIMDESNVL
3010
DSGFLERMNT
3020
LLANGEVPGL
3030
FEGDEYATLM
3040
TQCKEGAQKE
3050
GLMLDSHEEL
3060
YKWFTSQVIR
3070
NLHVVFTMNP
3080
SSEGLKDRAA
3090
TSPALFNRCV
3100
LNWFGDWSTE
3110
ALYQVGKEFT
3120
SKMDLEKPNY
3130
IVPDYMPVVY
3140
DKLPQPPTHR
3150
EAIVNSCVFV
3160
HQTLHQANAR
3170
LAKRGGRTMA
3180
ITPRHYLDFI
3190
NHYANLFHEK
3200
RSELEEQQMH
3210
LNVGLRKIKE
3220
TVDQVEELRR
3230
DLRIKSQELE
3240
VKNAAANDKL
3250
KKMVKDQQEA
3260
EKKKVMSQEI
3270
QEQLHKQQEV
3280
IADKQMSVKE
3290
DLDKVEPAVI
3300
EAQNAVKSIK
3310
KQHLVEVRSM
3320
ANPPAAVKLA
3330
LESICLLLGE
3340
STTDWKQIRS
3350
IIMRENFIPT
3360
IVNFSAEEIS
3370
DAIREKMKKN
3380
YMSNPSYNYE
3390
IVNRASLACG
3400
PMVKWAIAQL
3410
NYADMLKRVE
3420
PLRNELQKLE
3430
DDAKDNQQKA
3440
NEVEQMIRDL
3450
EASIARYKEE
3460
YAVLISEAQA
3470
IKADLAAVEA
3480
KVNRSTALLK
3490
SLSAERERWE
3500
KTSETFKNQM
3510
STIAGDCLLS
3520
AAFIAYAGYF
3530
DQQMRQNLFT
3540
TWSHHLQQAN
3550
IQFRTDIART
3560
EYLSNADERL
3570
RWQASSLPAD
3580
DLCTENAIML
3590
KRFNRYPLII
3600
DPSGQATEFI
3610
MNEYKDRKIT
3620
RTSFLDDAFR
3630
KNLESALRFG
3640
NPLLVQDVES
3650
YDPVLNPVLN
3660
REVRRTGGRV
3670
LITLGDQDID
3680
LSPSFVIFLS
3690
TRDPTVEFPP
3700
DLCSRVTFVN
3710
FTVTRSSLQS
3720
QCLNEVLKAE
3730
RPDVDEKRSD
3740
LLKLQGEFQL
3750
RLRQLEKSLL
3760
QALNEVKGRI
3770
LDDDTIITTL
3780
ENLKREAAEV
3790
TRKVEETDIV
3800
MQEVETVSQQ
3810
YLPLSTACSS
3820
IYFTMESLKQ
3830
VHFLYQYSLQ
3840
FFLDIYHNVL
3850
YENPNLKGAT
3860
DHTQRLSVIT
3870
KDLFQVAFNR
3880
VARGMLHQDH
3890
ITFAMLLARI
3900
KLKGTMGEPT
3910
YDAEFQHFLR
3920
GKEIVLSAGS
3930
TPKVQGLTVE
3940
QAEAVARLSC
3950
LPAFKDLIAK
3960
VQADEQFGIW
3970
LESSSPEQTV
3980
PYLWTEETPA
3990
TPIGQAIHRL
4000
LLIQAFRPDR
4010
LLAMAHMFVS
4020
TNLGESFMSI
4030
MEQPLDLTHI
4040
VGTEVKPNTP
4050
VLMCSVPGYD
4060
ASGHVEDLAA
4070
EQNTQITSIA
4080
IGSAEGFNQA
4090
DKAINTAVKS
4100
GRWVMLKNVH
4110
LAPGWLMQLE
4120
KKLHSLQPHA
4130
CFRLFLTMEI
4140
NPKVPVNLLR
4150
AGRIFVFEPP
4160
PGVKANMLRT
4170
FSSIPVSRMC
4180
KSPNERARLY
4190
FLLAWFHAVI
4200
QERLRYAPLG
4210
WSKKYEFGES
4220
DLRSACDTVD
4230
TWLDDTAKGR
4240
QNISPDKIPW
4250
SALKTLMAQS
4260
IYGGRVDNEF
4270
DQRLLNTFLE
4280
RLFTTRSFDS
4290
EFKLACKVDG
4300
HKDIQMPDGI
4310
RREEFVQWVE
4320
LLPDAQTPSW
4330
LGLPNNAERV
4340
LLTTQGVDMI
4350
SKMLKMQMLE
4360
DEDDLAYAET
4370
EKKTRTDSTS
4380
DGRPAWMRTL
4390
HTTASNWLHL
4400
IPQTLSPLKR
4410
TVENIKDPLF
4420
RFFEREVKMG
4430
AKLLQDVRQD
4440
LADVVQVCEG
4450
KKKQTNYLRT
4460
LINELVKGIL
4470
PRSWSHYTVP
4480
AGMTVIQWVS
4490
DFSERIKQLQ
4500
NISQAAAAGG
4510
AKELKNIHVC
4520
LGGLFVPEAY
4530
ITATRQYVAQ
4540
ANSWSLEELC
4550
LEVNVTASQS
4560
TTLDACSFGV
4570
TGLKLQGATC
4580
SNNKLSLSNA
4590
ISTVLPLTQL
4600
RWGKQTSAEK
4610
KASVVTLPVY
4620
LNFTRADLIF
4630
TVDFEIATKE
4640
DPRSFYERGV
AVLCTE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005868 | cytoplasmic dynein complex |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005874 | microtubule |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0045505 | dynein intermediate chain binding |
| Molecular Function | GO:0051959 | dynein light intermediate chain binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008569 | minus-end-directed microtubule motor activity |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0051293 | establishment of spindle localization |
| Biological Process | GO:0007018 | microtubule-based movement |
| Biological Process | GO:0033962 | P-body assembly |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:0032388 | positive regulation of intracellular transport |
| Biological Process | GO:1905832 | positive regulation of spindle assembly |
| Biological Process | GO:0090235 | regulation of metaphase plate congression |
| Biological Process | GO:0060236 | regulation of mitotic spindle organization |
| Biological Process | GO:0034063 | stress granule assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.