Search Results
Overview
| Uniprot ID | M0RAE4 |
|---|---|
| Protein Name | UBX domain-containing protein 6 |
| Gene Name | Ubxn6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 35 | GEKTSKGKSPQLALR |
Function
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes
Protein Sequence
10
MKKFFQEIKA
20
DIKFKSAGPG
30
QKLTDSAGEK
40
TSKGKSPQLA
50
LRQPRQGPTD
60
EAQMAAAAAL
70
ARLEQKQPRA
80
RGPTSQDSIR
90
NQGVTLRRDQ
100
RDAHIKQAIL
110
SHFSTDPVAA
120
SIMKIHTFNR
130
DRDRVKLGVD
140
TIAKYLDNIH
150
LHPEEEKYQK
160
IKLQNKVFQE
170
RINCLEGSHE
180
FFEAIGFKKV
190
TLPVPDQEGQ
200
EFYVLGEDAR
210
AQPQNLERHK
220
QQLLGAEPVR
230
ATLDRQLRVF
240
RPSALASHFE
250
LPSDFFSLTA
260
EEVKREQRLR
270
TEAVERLSSL
280
RTKAMREKEE
290
QRELRKYTYA
300
LLRVRLPDGC
310
LLQGTFYARE
320
KLSVLFQFVR
330
EALQNDWLPF
340
ELRASGGQKL
350
EENEALALNE
360
CGLVPSALLT
370
FSWDASVLED
380
IRAAGAEPAK
390
SVLRPELLAA
IEQLS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Biological Process | GO:0006950 | response to stress |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.