Overview
| Uniprot ID | M0RAX4 |
|---|
| Protein Name | Guanine nucleotide-binding protein subunit beta-5 |
|---|
| Gene Name | Gnb5 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 74 |
KLEEERAKLHDVELH |
Function
Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation. Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition. Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors. May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate
Protein Sequence
10
MCDQTFLVNV
20
FGSCDKCFKQ
30
RALRPVFKKS
40
QQLNYCSPCA
50
EIMATDGLHE
60
NETLASLKSE
70
AESLKGKLEE
80
ERAKLHDVEL
90
HQVAERVEAL
100
GQFVMKTRRT
110
LKGHGNKVLC
120
MDWCKDKRRI
130
VSSSQDGKVI
140
VWDSFTTNKE
150
HAVTMPCTWV
160
MACAYAPSGC
170
AIACGGLDNK
180
CSVYPLTFDK
190
NENMAAKKKS
200
VAMHTNYLSA
210
CSFTNSDMQI
220
LTASGDGTCA
230
LWDVESGQLL
240
QSFHGHGADV
250
LCLDLAPSET
260
GNTFVSGGCD
270
KKAMVWDMRS
280
GQCVQAFETH
290
ESDVNSVRYY
300
PSGDAFASGS
310
DDATCRLYDL
320
RADREVAIYS
330
KESIIFGASS
340
VDFSLSGRLL
350
FAGYNDYTIN
360
VWDVLKGSRV
370
SILFGHENRV
380
STLRVSPDGT
390
AFCSGSWDHT
LRVWA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0051286 |
cell tip |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0098688 |
parallel fiber to Purkinje cell synapse |
| Cellular Component |
GO:0045211 |
postsynaptic membrane |
| Cellular Component |
GO:0042734 |
presynaptic membrane |
| Molecular Function |
GO:0031682 |
G-protein gamma-subunit binding |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0051087 |
protein-folding chaperone binding |
| Biological Process |
GO:0007212 |
G protein-coupled dopamine receptor signaling pathway |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.